Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety

Breast Cancer : Basic and Clinical Research
Niamh O'HalloranAoife J Lowery

Abstract

Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer. This review aims to provide an overview of the potential role for ADSCs in breast reconstruction and to examine the evidence relating to the oncologic safety of their use in patients with breast cancer.

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Citations

Oct 20, 2018·Journal of Tissue Engineering and Regenerative Medicine·Niamh A O'HalloranGarry P Duffy
Dec 12, 2019·Journal of Tissue Engineering and Regenerative Medicine·Claudio ConciManuela T Raimondi
Jul 18, 2018·Frontiers in Endocrinology·Guojing LuoXijie Yu
Aug 1, 2018·International Journal of Molecular Sciences·Navneet Kumar DubeyWin-Ping Deng
Mar 7, 2020·Frontiers in Oncology·Roberta Fajka-BojaRóbert L Katona
Jul 7, 2019·International Journal of Molecular Sciences·Maria Giovanna ScioliAugusto Orlandi
Mar 9, 2021·Annals of the Royal College of Surgeons of England·M MughalP Roblin
Oct 14, 2019·ACS Biomaterials Science & Engineering·Wooyeol BaekHak-Joon Sung

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Methods Mentioned

BETA
surgical resection

Clinical Trials Mentioned

NCT01035268

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