Adipose-derived Stem Cells Stimulated with n-Butylidenephthalide Exhibit Therapeutic Effects in a Mouse Model of Parkinson's Disease

Cell Transplantation
Kang ChiShih-Ping Liu

Abstract

Parkinson's disease (PD) causes motor dysfunction and dopaminergic cell death. Drug treatments can effectively reduce symptoms but often cause unwanted side effects. Stem cell therapies using cell replacement or indirect beneficial secretomes have recently emerged as potential therapeutic strategies. Although various types of stem cells have been proposed as possible candidates, adipose-derived stem cells (ADSCs) are easily obtainable, more abundant, less ethically disputed, and able to differentiate into multiple cell lineages. However, treatment of PD using adult stem cells is known to be less efficacious than neuron or embryonic stem cell transplantation. Therefore, improved therapies are urgently needed. n-Butylidenephthalide (BP), which is extracted from Angelica sinensis, has been shown to have anti-inflammatory and neuroprotective effects. Indeed, we previously demonstrated that BP treatment of ADSCs enhances the expression of neurogenesis and homing factors such as nuclear receptor related 1 protein, stromal-derived factor 1, and brain-derived neurotrophic factor. In the present study, we examined the ability of BP-pretreated ADSC transplantation to improve PD motor symptoms and protect dopamine neurons in a mouse model...Continue Reading

References

Apr 2, 1999·Science·M F PittengerD R Marshak
Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
May 25, 2004·Science·J Timothy Greenamyre, Teresa G Hastings
May 23, 2006·Lancet Neurology·Lonneke M L de Lau, Monique M B Breteler
May 15, 2007·Circulation Research·Jeffrey M GimbleBruce A Bunnell
Aug 25, 2007·Experimental Brain Research·Yan YuZhong-Ming Qian
May 2, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shih-Hao HuangBeen-Huang Chiang
Jun 20, 2008·Stem Cells and Development·Elena AnghileriBruno Bonetti
Aug 1, 2008·Journal of Chromatography. a·Lunzhao YiDalin Yuan
Mar 20, 2009·Human Molecular Genetics·Suzanne Lesage, Alexis Brice
Nov 19, 2010·Regenerative Medicine·Nanette JoyceJan A Nolta
Mar 25, 2011·Methods in Molecular Biology·Katarzyna A Trzaska, Pranela Rameshwar
Jun 16, 2012·Clinical Reviews in Allergy & Immunology·Cindy L H YangAllan S Y Lau
Jul 4, 2012·The Journal of Clinical Investigation·Yosif M GanatLorenz Studer
Jul 26, 2012·Annals of Neurology·Phil Hyu LeeYoung H Sohn
Nov 13, 2013·JAMA Neurology·Zinovia KefalopoulouThomas Foltynie
Jun 7, 2015·Clinical and Experimental Medicine·Ruslan F MasgutovAlbert A Rizvanov
Sep 1, 2016·Journal of Neurochemistry·Wolfgang Oertel, Jörg B Schulz

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Citations

Dec 12, 2018·Frontiers in Physiology·Yulia A PaninaAlla B Salmina
Mar 1, 2020·Stem Cells and Development·Zhenzhong ZhongQinghua Wang
Jun 30, 2019·Integrative Biology : Quantitative Biosciences From Nano to Macro·Khaled YoussefPouya Rezai
Dec 17, 2020·Neuropsychiatric Disease and Treatment·Yuan Wang, Miao Peng
Jan 15, 2021·International Journal of Molecular Sciences·Ka Young Kim, Keun-A Chang
Jul 3, 2021·Metabolic Brain Disease·Xiaorong ZhaoBo Niu

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Datasets Mentioned

BETA
AB3598

Methods Mentioned

BETA
Polymerase Chain Reaction
PCR
light microscopy
confocal microscopy

Software Mentioned

SigmaPlot

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