Adipose-specific deletion of stearoyl-CoA desaturase 1 up-regulates the glucose transporter GLUT1 in adipose tissue.

Biochemical and Biophysical Research Communications
Chang-Kee HyunJames M Ntambi

Abstract

Stearoyl-CoA desaturase 1 (SCD1) deficiency protects mice from diet-induced obesity and insulin resistance. To understand the tissue-specific role of SCD1 in energy homeostasis, we have generated mice with an adipose-specific knockout of Scd1 (AKO), and report here that SCD1 deficiency increases GLUT1 expression in adipose tissue of AKO mice, but not global SCD1 knockout (GKO) mice. In 3T3-L1 adipocytes treated with an SCD inhibitor, basal glucose uptake and the cellular expression of GLUT1 were significantly increased while GLUT4 expression remained unchanged. Consistently, adipose-specific SCD1 knockout (AKO) mice had significantly elevated GLUT1 expression, but not GLUT4, in white adipose tissue compared to Lox counterparts. Concurrently, adiponectin expression was significantly diminished, whereas TNF-alpha expression was elevated. In contrast, in adipose tissue of GKO mice, GLUT4 and adiponectin expression were significantly elevated with lowered TNF-alpha expression and little change in GLUT1 expression, suggesting a differential responsiveness of adipose tissue to global- or adipose-specific SCD1 deletion. Taken together, these results indicate that adipose-specific deletion of SCD1 induces GLUT1 up-regulation in adipose...Continue Reading

References

Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·James M NtambiAlan D Attie
Jul 15, 2003·American Journal of Physiology. Endocrinology and Metabolism·Ilana TaliorHagit Eldar-Finkelman
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Pawel DobrzynJames M Ntambi
Oct 21, 2004·American Journal of Physiology. Endocrinology and Metabolism·Shaikh Mizanoor RahmanJames M Ntambi
Nov 25, 2004·American Journal of Physiology. Endocrinology and Metabolism·Agnieszka DobrzynJames M Ntambi
Dec 1, 2004·The Journal of Nutrition·Chang-Kee HyunSusan C Frost
Jul 11, 2006·The Journal of Clinical Investigation·Mark A Herman, Barbara B Kahn
Dec 15, 2006·Nature·Evan D Rosen, Bruce M Spiegelman
Nov 6, 2007·Biological & Pharmaceutical Bulletin·So Hui KimChang-Kee Hyun
Nov 27, 2007·Nature Clinical Practice. Rheumatology·Francisca LagoOreste Gualillo
May 8, 2008·Current Opinion in Lipidology·Matthew T Flowers, James M Ntambi
Jul 18, 2008·Bioorganic & Medicinal Chemistry Letters·Zhili XinGang Liu
Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Neda Rasouli, Philip A Kern
Mar 3, 2009·Biological & Pharmaceutical Bulletin·Eun-Do KimChang-Kee Hyun
May 7, 2009·Cell Metabolism·Bei B ZhangCai Li

❮ Previous
Next ❯

Citations

Feb 26, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J C RalstonD M Mutch
Mar 5, 2013·The Journal of Biological Chemistry·Min LuJerrold M Olefsky
Jan 10, 2016·Biochimica Et Biophysica Acta·Raghavendra MysoreVesa M Olkkonen
Sep 25, 2012·Progress in Lipid Research·Leanne Hodson, Barbara A Fielding
Jan 4, 2012·Annals of the New York Academy of Sciences·Harini Sampath, James M Ntambi
Dec 5, 2012·ISRN Endocrinology·Laura C OrtinauJames W Perfield
May 12, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Jessica C Ralston, David M Mutch
Jan 2, 2018·World Journal of Gastroenterology : WJG·Xiao-Lin LiuJian-Gao Fan
Aug 25, 2018·Journal of Lipid Research·Pallavi MukherjeeAlan M Fogelman
Sep 17, 2013·Metabolomics : Official Journal of the Metabolomic Society·Jennifer K YeeWai-Nang P Lee
Dec 21, 2013·The Journal of Biological Chemistry·Harini Sampath, James M Ntambi
Oct 6, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Laura A ForneyThomas W Gettys
Mar 17, 2011·Journal of Biomolecular Screening·Paul TawaKathryn Skorey
Jan 10, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Laura ButruilleDelphine Eberlé
Aug 24, 2021·The Journal of Experimental Biology·Bryon F Tuthill IiLaura Palanker Musselman

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.