Adipose tissue-derived stem cells as a therapeutic tool for cardiovascular disease

World Journal of Cardiology
Etsu SuzukiHiroaki Nishimatsu

Abstract

Adipose tissue-derived stem cells (ADSCs) are adult stem cells that can be easily harvested from subcutaneous adipose tissue. Many studies have demonstrated that ADSCs differentiate into vascular endothelial cells (VECs), vascular smooth muscle cells (VSMCs), and cardiomyocytes in vitro and in vivo. However, ADSCs may fuse with tissue-resident cells and obtain the corresponding characteristics of those cells. If fusion occurs, ADSCs may express markers of VECs, VSMCs, and cardiomyocytes without direct differentiation into these cell types. ADSCs also produce a variety of paracrine factors such as vascular endothelial growth factor, hepatocyte growth factor, and insulin-like growth factor-1 that have proangiogenic and/or antiapoptotic activities. Thus, ADSCs have the potential to regenerate the cardiovascular system via direct differentiation into VECs, VSMCs, and cardiomyocytes, fusion with tissue-resident cells, and the production of paracrine factors. Numerous animal studies have demonstrated the efficacy of ADSC implantation in the treatment of acute myocardial infarction (AMI), ischemic cardiomyopathy (ICM), dilated cardiomyopathy, hindlimb ischemia, and stroke. Clinical studies regarding the use of autologous ADSCs for tre...Continue Reading

Citations

Jan 25, 2018·Aesthetic Surgery Journal·Semra UyulmazNicole Lindenblatt
Jul 29, 2016·Plastic and Reconstructive Surgery·Derek A BanyardAlan D Widgerow
Feb 12, 2017·Stem Cells Translational Medicine·Jordan A DykstraDaniel J Kota
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Aug 15, 2018·Cardiovascular Drugs and Therapy·Joshua M BoucherLucy Liaw
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Sep 1, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Marina MantovaniPaola Rosalba Russo

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