Adipose tissue failure and mitochondria as a possible target for improvement by bioactive food components

Current Opinion in Lipidology
Jaap Keijer, Evert M van Schothorst

Abstract

Adipose tissue is an essential, highly dynamic and metabolically active tissue that vigorously communicates to support its primary function: the storage of lipids. It performs this function to secure energy supply and prevent lipotoxicity. Adipose tissue is essential for maintaining a healthy glucose and lipid homeostasis and failure results in disease. This review discusses causes of adipose tissue failure and four categories of bioactive food components that may help to prevent this. Based on recent findings, it is argued that initial adipose failure following long-term excess energy intake may be the result of reduced mitochondrial capacity associated with altered mitochondrial reactive oxygen species signaling and adipose tissue hypoxia. Current data suggest that different classes of bioactive food components, including vitamin B3, retinoids, fatty acids and polyphenols, may have the potential to modulate mitochondrial function and consequently prevent adipose dysfunction in obesity. It seems most attractive to aim nutritional intervention at the prevention of initial adipose dysfunction and hence to target dietary intervention at improvement of mitochondrial function.

References

Feb 17, 2000·The Journal of Clinical Investigation·O GavrilovaM L Reitman
Jan 10, 2002·Genes & Development·Evan D RosenBruce M Spiegelman
Feb 21, 2002·The Journal of Biological Chemistry·Dieter KresslerAnastasia Kralli
Jun 17, 2003·The Journal of Biological Chemistry·Jiandie LinBruce M Spiegelman
Aug 26, 2003·FEBS Letters·Audrey CarrièreLouis Casteilla
Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yasutomi KameiAkira Kakizuka
Oct 15, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R K SempleS O'Rahilly
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Dec 18, 2003·The Journal of Clinical Investigation·Haiyan XuHong Chen
Feb 27, 2004·The American Journal of Clinical Nutrition·Antonius H M Terpstra
Mar 9, 2004·Genes & Development·Daniel P Kelly, Richard C Scarpulla
Mar 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·May FarajKatherine Cianflone
Apr 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sylvia N SchreiberAnastasia Kralli
Apr 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Vamsi K MoothaBruce M Spiegelman
May 18, 2004·Nature Biotechnology·Baoxiu QiColin M Lazarus
Aug 11, 2004·Molecular Aspects of Medicine·Michael R Duchen
Sep 11, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Patrick F Shen
Oct 16, 2004·Science·Umut OzcanGökhan S Hotamisligil
Nov 13, 2004·The Journal of Biological Chemistry·Ying LinPhilipp E Scherer
Nov 26, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takatoshi MuraseIchiro Tokimitsu
Dec 14, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C Lelliott, A J Vidal-Puig
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Jan 8, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Josep Maria Del BasCinta Bladé
Jan 11, 2005·Médecine sciences : M/S·Claire Tiraby, Dominique Langin
Feb 16, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P Puigserver
Mar 1, 2005·Cell·Leonard Guarente, Frédéric Picard
Mar 2, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S KlausS Wolfram
Mar 5, 2005·Journal of the American Dietetic Association·Joyce A Nettleton, Robert Katz
Mar 12, 2005·Obesity Research·UNKNOWN Federacion Latinoamericana de Sociedades de Obesidad (FLASO) Federation of Latin American Societies of ObesityUNKNOWN International Association for the Study of Obesity (IASO)
Mar 16, 2005·Nature Reviews. Molecular Cell Biology·Laura Bordone, Leonard Guarente
Apr 6, 2005·Biochemistry. Biokhimii︠a︡·A Yu AndreyevA A Starkov
May 28, 2005·Obesity Research·Martin RossmeislJan Kopecky
Jun 7, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Cinti

❮ Previous
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Citations

Feb 18, 2011·Current Diabetes Reports·Jianping Ye
Dec 4, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J Ye
May 26, 2011·Journal of Molecular Endocrinology·Loes P M DuivenvoordeJaap Keijer
Sep 8, 2010·World Journal of Gastroenterology : WJG·Mohamed-H Ahmed, Christopher-D Byrne
Apr 20, 2014·Mediators of Inflammation·Assunta RaiolaAmalia Barone
Jun 24, 2014·The International Journal of Biochemistry & Cell Biology·Li WangConstance Tom Noguchi
Nov 18, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Marijana TodorcevićBente Ruyter
Jul 5, 2008·Cancer Letters·J A Milner
Dec 5, 2009·Molecular Nutrition & Food Research·Cinta BladéMaria-Josepa Salvadó
Aug 25, 2009·The American Journal of Pathology·Aurélia De PauwThierry Arnould
Sep 29, 2011·Journal of Hepatology·Maud Lemoine, Lawrence Serfaty
Jan 22, 2013·Biochemical and Biophysical Research Communications·Min-Kyung JangMyeong Ho Jung
Apr 16, 2015·Mediators of Inflammation·Elena PaschettaValerio Nobili
Nov 21, 2009·Medicine and Science in Sports and Exercise·David C NiemanDru A Henson
Oct 9, 2019·International Journal of Molecular Sciences·Jae Ho LeeKwang-Hee Bae
Nov 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Evert M van SchothorstJaap Keijer
Jun 16, 2011·Physiological Genomics·Evert M van SchothorstJaap Keijer

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