Adipose Tissue Inflammation and Adrenomedullin Overexpression Contribute to Lipid Dysregulation in Diabetic Pregnancies

The Journal of Clinical Endocrinology and Metabolism
Yuan-Lin DongChandra Yallampalli

Abstract

Impaired maternal lipid metabolism in gestational diabetes mellitus (GDM) has detrimental effects on maternal health and fetal growth. We previously reported the excessive expression of adrenomedullin (ADM) and its receptors in GDM adipose tissues compared with normal glucose-tolerant pregnancies. In the present study, we determined the mechanisms underlying enhanced expression of ADM and its receptors. Omental adipose tissue (OAT) samples were collected from women during cesarian section of term pregnancy with nonoverweight (NOW; n = 9), overweight (OW; n = 8), obese (OBS; n = 10), and GDM (n = 10) status. The expression of ADM and its receptors was greater in OATs from GDM than from women who were NOW, OW, and OBS. The expression of adipokines, leptin, and resistin were significantly increased, but adiponectin was decreased in OATs from patients with GDM compared with those without GDM. Macrophage infiltration and TNF-α expression were greater in OAT from pregnant women with GDM than in pregnant women without GDM. Furthermore, TNF-α dose dependently increased mRNA for ADM and its receptor components calcitonin receptor-like receptor and receptor activity-modifying proteins 2 and 3 in OAT explants from women who were NOW. Huma...Continue Reading

References

Nov 26, 1997·Lancet·M HayashiT Fujita
Sep 7, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R Di IorioC Letizia
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Patrick M CatalanoJacob E Friedman
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Mar 15, 2006·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Alaina ArochoQiulu Pan
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Nov 6, 2007·Clinical Obstetrics and Gynecology·Kristine Y Lain, Patrick M Catalano
May 23, 2008·Acta Diabetologica·Harry M GeorgiouGregory E Rice
May 29, 2009·Reproductive Sciences·Despina D Briana, Ariadne Malamitsi-Puchner
Sep 3, 2009·Molecular and Cellular Endocrinology·Sandra GalicGregory R Steinberg
Feb 1, 2006·Expert Review of Pharmacoeconomics & Outcomes Research·Roselle L Cripps, Susan E Ozanne
Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Emilio Herrera, Henar Ortega-Senovilla
Sep 29, 2011·Clinical Endocrinology·Konstanze MiehleMathias Fasshauer
Aug 24, 2012·The Proceedings of the Nutrition Society·Orla M FinucaneHelen M Roche
Dec 18, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Katarzyna Bergmann, Grazyna Sypniewska
Feb 19, 2013·Cell·Andrew M F Johnson, Jerrold M Olefsky
Dec 24, 2013·American Journal of Obstetrics and Gynecology·Nansi S BoghossianCuilin Zhang
Mar 13, 2014·BMJ : British Medical Journal·Tim CundyEdmond A Ryan
Apr 16, 2014·The Lancet. Diabetes & Endocrinology·Mathias FasshauerMichael Stumvoll
May 8, 2014·Endokrynologia Polska·Marzena WójcikKatarzyna Cypryk
Oct 30, 2015·Biology of Reproduction·Yuanlin DongChandrasekhar Yallampalli
Oct 30, 2015·Biology of Reproduction·Madhu Lata S ChauhanChandrasekhar Yallampalli
Jun 7, 2017·Advances in Experimental Medicine and Biology·Ayse Basak Engin
Jul 2, 2017·The Journal of Clinical Endocrinology and Metabolism·Yuanlin DongChandrasekhar Yallampalli

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Citations

Jan 17, 2020·International Journal of Molecular Sciences·Rebecca C RancourtAndreas Plagemann
Dec 2, 2020·Scientific Reports·Kathleen A PenningtonChandrasekhar Yallampalli
Oct 12, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Roman V KapustinOlga N Arzhanova

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