Adipose tissue levels of polybrominated diphenyl ethers and breast cancer risk in Chinese women: A case-control study

Environmental Research
Yuanfang HeKusheng Wu

Abstract

Polybrominated diphenyl ethers (PBDEs) are suspected to be associated with breast cancer risk because of their estrogenic potencies. Epidemiological studies of PBDEs and breast cancer are scarce. Our study aimed to estimate the association between adipose-tissue PBDE concentrations and breast cancer risk. A total of 209 breast cancer cases and 165 controls were recruited from hospitals between January 2014 and May 2016 in Shantou, Chaoshan area, China. Concentrations of 14 PBDE congeners were measured in adipose tissues obtained from the breast for cases and the abdomen/breast for controls during surgery. Demographic and clinicopathologic characteristics were obtained from medical records. Breast cancer risk as well as clinicopathologic characteristics were evaluated by adipose-tissue PBDE level. Odds ratios (ORs) and 95% confidence intervals (95% CIs) for breast cancer risk associated with levels of PBDE congeners were estimated from logistic regression models for all cases and stratified by estrogen receptor (ER) status. Level of total PBDEs (∑PBDE) and most individual PBDE congeners were higher in breast cancer cases than controls (median ∑PBDE, 94.99 vs 73.72 ng/g lipid). In the adjusted univariate model for all cases, brea...Continue Reading

Citations

Apr 6, 2019·Archives of Environmental Contamination and Toxicology·Adela Jing LiKurunthachalam Kannan
May 31, 2020·International Journal of Environmental Research and Public Health·Giulia SimonettiFrancesca Buiarelli
Oct 28, 2019·International Journal of Environmental Research and Public Health·Hana LogerováPavel Dlouhý
Jul 5, 2019·Environmental Science and Pollution Research International·Zhineng WuYingying Wang
May 22, 2020·Environmental Health : a Global Access Science Source·Francesca Romana ManciniMarina Kvaskoff
Oct 22, 2020·Environmental Science and Pollution Research International·Yaomin LuoWeiling Sun
Oct 3, 2018·Environmental Research·Joaquim Rovira, José L Domingo
Apr 6, 2021·Critical Reviews in Food Science and Nutrition·Murphy Lam Yim WanHani El-Nezami
Apr 17, 2021·Critical Reviews in Oncology/hematology·Priscilla Roberta Silva RochaAngélica Amorim Amato
May 1, 2021·International Journal of Molecular Sciences·Chander K NegiLuděk Bláha
Jun 22, 2021·Journal of Environmental Health Science & Engineering·Chinemerem Ruth OhoroOmobola Oluranti Okoh
Oct 17, 2021·Environmental Science and Pollution Research International·Ciro Alberto de Oliveira RibeiroFilipak Neto

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