Adipose Tissue Lipokines: Recent Progress and Future Directions.

Diabetes
Veronica L LiJonathan Z Long

Abstract

Beyond classical metabolic functions in energy storage and energy expenditure, adipose tissue is also a dynamic endocrine organ that secretes bioactive factors into blood plasma. Historically, studies of the adipose secretome have predominantly focused on polypeptide adipokines. Recently, adipose-derived blood-borne lipids ("lipokines") have emerged as a distinct class of endocrine factors. Lipokines are intimately connected to intracellular pathways of fatty acid metabolism and therefore uniquely poised to communicate the intracellular energy status of adipocytes to other nonadipose tissues including liver, muscle, and pancreas. Here, we discuss recent progress on our understanding of adipose-secreted lipokines as endocrine regulators of glucose and lipid metabolism. We also provide our perspective on future directions for adipose-secreted lipids, including limitations of the currently available experimental data as well as potential strategies for addressing the remaining open questions.

References

May 1, 1997·Nature Medicine·M F MoghaddamB D Hammock
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·James M NtambiAlan D Attie
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Erin E Kershaw, Jeffrey S Flier
Nov 6, 2009·Diabetes Care·Norbert StefanHans-Ulrich Häring
Jan 27, 2011·Journal of Lipid Research·Elisa FabbriniSamuel Klein
Mar 23, 2011·Journal of Lipid Research·Rodolphe DusaulcyJean Sébastien Saulnier-Blache
Mar 29, 2016·Nature Chemical Biology·William H ParsonsBenjamin F Cravatt
Aug 3, 2017·Cell Metabolism·Susanne KeipertMartin Jastroch
Sep 19, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Susann FayyazBurkhard Kleuser
May 3, 2018·Cell Metabolism·Kristin I StanfordLaurie J Goodyear
Jul 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jonathan Z LongBruce M Spiegelman
Sep 25, 2018·Cell Metabolism·Ismail SyedBarbara B Kahn
Jun 4, 2019·Cell Metabolism·Wenshan WangPatrick Seale
Jul 13, 2019·Nature Reviews. Endocrinology·Ludger Scheja, Joerg Heeren
Aug 6, 2019·The Journal of Clinical Investigation·Ismail SyedBarbara B Kahn
Aug 27, 2019·The Journal of Clinical Investigation·Peng ZhouBarbara B Kahn
Oct 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Kiara K BensonRaymond E Soccio
Mar 11, 2020·The Journal of Biological Chemistry·Meric Erikci ErtuncAlan Saghatelian
May 14, 2020·Cell Chemical Biology·Joon T KimJonathan Z Long

❮ Previous
Next ❯

Citations

Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jean A BoutinKarine Puget
Apr 8, 2021·Cell Metabolism·Anna SantoroBarbara B Kahn
Apr 29, 2021·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Paul E Neumann, Eve E Neumann
Jul 25, 2021·International Journal of Molecular Sciences·Lowell DilworthFelix Omoruyi
Sep 18, 2021·Current Opinion in Rheumatology·Neža BrezovecKatja Lakota

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Related Papers

Nutrients
Diego Hernández-Saavedra, Kristin I Stanford
Endocrinology
Matthew D LynesYu-Hua Tseng
The EMBO Journal
Alexandros VegiopoulosStephan Herzig
Gaceta médica de México
María E Frigolet, Ruth Gutiérrez-Aguilar
© 2021 Meta ULC. All rights reserved