Adipose tissue mitochondrial respiration and lipolysis before and after a weight loss by diet and RYGB

Obesity
Merethe HansenFlemming Dela

Abstract

To study adipose tissue mitochondrial respiration and lipolysis following a massive weight loss. High resolution respirometry of adipose tissue biopsies and tracer determined whole body lipolysis. Sixteen obese patients with type 2 diabetes (T2DM) and 27 without (OB) were studied following a massive weight loss by diet and Roux-en-Y gastric bypass (RYGB). The mitochondrial respiratory rates were similar in OB and T2DM, and the mass-specific oxygen flux increased significantly 4 and 18 months post-surgery (P < 0.05). With normalization to mitochondrial content, no differences in oxidative capacity after RYGB were seen. The ratio between the oxidative phosphorylation system capacity (P) and the capacity of the electron transfer system (E) increased 18 months after RYGB in both groups (P < 0.05). Lipolysis per fat mass was similar in the two groups and was increased (P < 0.05) and lipid oxidation during hyperinsulinemia decreased 4 months post-surgery. In T2DM, visceral fat mass was always higher relative to the body fat mass (%) compared to OB. Adipose tissue mitochondrial respiratory capacity increases with RYGB. Adipocytes adapt to massive weight loss by increasing the phosphorylation system ratio (P/E), suggesting an increased...Continue Reading

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Citations

Sep 24, 2015·Obesity·Rebecca E K MacPherson, David C Wright
Jun 9, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H Frikke-SchmidtR J Seeley
May 6, 2016·Annual Review of Nutrition·Chrysi Koliaki, Michael Roden
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Jul 10, 2019·Scandinavian Journal of Medicine & Science in Sports·Camila Fernanda Cunha BrandaoJulio Sergio Marchini
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Jun 3, 2021·International Journal of Molecular Sciences·Tiago MoraisMariana P Monteiro

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