Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes

Obesity
Zuzana KovacovaRichard E Pratley

Abstract

Cardiac natriuretic peptides (NPs) bind to two receptors (NPRA-mediator of signaling; NPRC-clearance receptor) whose ratio, NPRR (NPRA/NPRC), determines the NP bioactivity. This study investigated the relationship of NP receptor gene expression in adipose tissue and muscle with obesity and glucose intolerance. Prospectively, the study also assessed whether changes in NP receptor expression and thermogenic gene markers accompanied improvements of insulin sensitivity. A cross-sectional study of subjects with a wide range of BMI and glucose tolerance (n = 50) was conducted, as well as a randomized 12-week trial of subjects with type 2 diabetes mellitus (T2DM) treated with pioglitazone (n = 9) or placebo (n = 10). NPRR mRNA was significantly lower in adipose tissue of subjects with obesity when compared with lean subjects (P ≤ 0.001). NPRR decreased with progression from normal glucose tolerance to T2DM (P < 0.01) independently of obesity. Treatment of subjects with T2DM with pioglitazone increased NPRR in adipose tissue (P ≤ 0.01) in conjunction with improvements in insulin sensitivity and increases of the thermogenic markers PPARγ coactivator-1α and uncoupling protein 1 (P ≤ 0.01). Decreased adipose tissue NPRR was associated wit...Continue Reading

References

Dec 1, 1993·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·R SarzaniA Rappelli
Oct 1, 1996·Journal of Endocrinological Investigation·R SarzaniA Rappelli
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·N MatsukawaO Smithies
Jul 6, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C SengenèsJ Galitzky
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
Jan 12, 2001·The Journal of Biological Chemistry·L R Potter, T Hunter
Oct 15, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R K SempleS O'Rahilly
Dec 18, 2003·The American Journal of Medicine·Vivian Fonseca
Feb 11, 2004·Circulation·Thomas J WangRamachandran S Vasan
Mar 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Andreas L BirkenfeldJens Jordan
Aug 2, 2005·Cell Metabolism·Jiandie LinBruce M Spiegelman
Mar 14, 2008·Trends in Endocrinology and Metabolism : TEM·Max LafontanJean Galitzky
Oct 7, 2008·Diabetes·Andreas L BirkenfeldJens Jordan
Jan 12, 2010·Biochemical and Biophysical Research Communications·Hideaki NakatsujiIichiro Shimomura
Mar 8, 2011·The FEBS Journal·Lincoln R Potter
Aug 6, 2011·Canadian Journal of Physiology and Pharmacology·Kailash N Pandey
Feb 4, 2012·Genes & Development·Ffolliott M FisherBruce M Spiegelman
Feb 7, 2012·The Journal of Clinical Investigation·Marica BordicchiaSheila Collins
Aug 24, 2012·Disease Models & Mechanisms·Saverio Cinti
Nov 2, 2012·The Journal of Clinical Investigation·Stefan EngeliCedric Moro
Dec 4, 2013·Nature Reviews. Endocrinology·Sheila Collins

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Citations

Jul 18, 2017·Expert Review of Cardiovascular Therapy·Marcela Rodriguez FloresPaul Poirier
Sep 28, 2017·Hormone Molecular Biology and Clinical Investigation·Fubiao Shi, Sheila Collins
Feb 7, 2018·The Journal of Clinical Endocrinology and Metabolism·Caitlin A MurphySuman Srinivasa
Jan 4, 2019·Circulation Research·Helena C Kenny, E Dale Abel
Jan 4, 2018·Endocrine Connections·Signe FrøssingJens Faber
May 15, 2018·PloS One·Katherine N BachmannThomas J Wang
Sep 14, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K VerbovenE E Blaak
Apr 22, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M BordicchiaR Sarzani
Aug 21, 2019·Frontiers in Cardiovascular Medicine·Albin OhMaria Valero-Muñoz
May 21, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Alexander E Berezin, Alexander A Berezin
Oct 28, 2016·Expert Opinion on Therapeutic Targets·Cedric Moro
Jul 4, 2020·European Journal of Heart Failure·Vishal N RaoG Michael Felker
Dec 29, 2020·Frontiers in Physiology·Claire LaurensCedric Moro
Feb 8, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Frankie B StentzChris Sands
May 8, 2021·Journal of the American College of Cardiology·Vibhu ParchaPankaj Arora
Jun 27, 2021·Pflügers Archiv : European journal of physiology·Natalia Lucía Rukavina MikusicMarcelo Roberto Choi
Aug 7, 2021·Antioxidants·Ursula Abou-Rjeileh, G Andres Contreras
Aug 17, 2021·Frontiers in Genetics·Adeline DivouxSteven R Smith
Dec 18, 2021·European Journal of Heart Failure·Alice M JacksonUNKNOWN PARAGON-HF Committees and Investigators

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Methods Mentioned

BETA
biopsies
biopsy
Assay
PCR

Clinical Trials Mentioned

NCT00656864

Software Mentioned

SAS
Statistical Analysis System ( SAS )
ImageJ
GraphPad
GraphPad Prism
MINMOD

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