Adipose tissue stimulates bone growth in prepubertal children.

The Journal of Clinical Endocrinology and Metabolism
E M ClarkJ H Tobias

Abstract

Fat mass represents a positive influence on bone mass in adults, independently of other factors such as lean mass, but whether a similar action occurs in children is unclear. Our objective was to examine the relationship between fat mass and bone mass in children. We conducted combined cross-sectional and prospective analyses at university research clinics. Participants included children aged 9.9 yr from a large population-based birth cohort in southwest England. Relationships between total body fat mass were measured by dual-energy x-ray absorptiometry at age 9.9 yr, and 1) total-body-less-head bone mass and area at age 9.9 and 2) increase in bone mass and area over the following 2 yr. There was a strong positive relationship between total body fat mass and total-body-less-head bone mass and area, even after adjustment for height and/or lean mass (P < 0.001). There was a similar positive association between total body fat mass and increase in bone mass and area over the following 2 yr in boys and Tanner stage 1 girls. In contrast, no association was present between fat mass and gain in bone mass and size in Tanner stage 2 girls, whereas a negative association was seen in Tanner stage 3 girls (puberty-fat mass interaction, P < ...Continue Reading

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