Adipose Y5R mRNA is higher in obese than non-obese humans and is correlated with obesity parameters

Experimental Biology and Medicine
Saimai ChatreeSupornpim Chearskul

Abstract

Neuropeptide Y is mainly expressed in the central nervous system to regulate food intake via its receptors, Y receptors, and in various peripheral tissues including adipose tissue. The objectives of this study were to compare Y5R mRNA and adipocyte parameters consisting of area, width, height, and perimeter either between obese and non-obese subjects or between subcutaneous and visceral fat as well as to compare between NPY, Y1R, Y2R, and Y5R mRNA expressions in subcutaneous and visceral adipose tissues. In subcutaneous and visceral adipose tissues, Y5R was greater in obese than in non-obese humans (both P < 0.05). Y1R mRNA expression was highest followed by Y5R, Y2R, and NPY mRNA expressions, respectively, in subcutaneous and visceral adipose tissues. Visceral Y5R mRNA had positive correlations with body weight, body mass index, waist circumference, hip circumference (R ≍ 0.4), and visceral Y1R mRNA (R = 0.773), but had a negative correlation with the quantitative insulin sensitivity check index (R=-0.421) (all P < 0.05). Subcutaneous and visceral adipocyte parameters were positively correlated with body weight, waist circumference, hip circumference, and waist-to-hip ratio, with greater values of correlation coefficient shown...Continue Reading

References

May 15, 1997·The Journal of Clinical Investigation·F LönnqvistP Arner
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
Aug 31, 2001·Bioorganic & Medicinal Chemistry Letters·C P KordikA B Reitz
Nov 20, 2002·Annals of the New York Academy of Sciences·Claudia CavadasEric Grouzmann
May 14, 2005·Current Opinion in Lipidology·Rudolf ZechnerRobert Zimmermann
May 18, 2005·Obesity Research·Britt G GabrielssonLena M S Carlsson
Nov 11, 2005·The American Journal of Clinical Nutrition·Dennis T VillarealUNKNOWN NAASO, The Obesity Society
Sep 6, 2007·Endocrine Reviews·M M Kamiji, A Inui
Sep 6, 2007·American Journal of Physiology. Endocrinology and Metabolism·Katarina KosSudhesh Kumar
Mar 8, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kaiping YangXiang Cao
Sep 27, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M LundgrenJ W Eriksson
Jan 30, 2009·Diabetes, Obesity & Metabolism·K KosP G McTernan
Jun 2, 2009·European Journal of Pharmacology·Satoshi MashikoAkio Kanatani
Aug 7, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Mohsen Ibrahim
Mar 27, 2010·The Chinese Journal of Physiology·Hong-yan WuHui-fang Zhang
Dec 1, 2010·Journal of Pediatric Gastroenterology and Nutrition·Irena Aldhoon Hainerová, Jan Lebl
May 7, 2011·British Journal of Pharmacology·Ernie YulyaningsihAmanda Sainsbury
Feb 6, 2013·Frontiers in Endocrinology·Xavier Pedragosa-BadiaAnnette G Beck-Sickinger
Sep 4, 2015·American Journal of Physiology. Endocrinology and Metabolism·Amaia RodriguezGema Frühbeck
Feb 13, 2016·Lancet·George A BrayJohn P H Wilding

❮ Previous
Next ❯

Citations

Feb 15, 2019·Experimental Biology and Medicine·Roongrit KlinjampaTripop Lertbunnaphong
Sep 21, 2020·The International Journal of Neuropsychopharmacology·Lauren A StoneRonald S Duman
Nov 2, 2020·Peptides·Chantacha SitticharoonRungnapa Sririwichitchai

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

AxioVision®

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.