Adiposity and metabolic dysfunction in polycystic ovary syndrome

Hormone Molecular Biology and Clinical Investigation
Susan Sam

Abstract

Polycystic ovary syndrome (PCOS) is the most common hormonal disorder among reproductive-age women and is associated with a high risk for metabolic disorders. Adiposity and insulin resistance are two prevalent conditions in PCOS and the likely culprits for the heightened metabolic risk. Up to 60% of women with PCOS are considered to be overweight or obese, and even among non-obese women with PCOS there is an increased accumulation of adipose tissue in abdominal depots. Insulin resistance in PCOS is unique and independent of obesity, as even non-obese women with this condition are frequently insulin resistant. However, obesity substantially aggravates the insulin resistance and the metabolic and reproductive abnormalities in women with PCOS. Recently, it has been shown that many aspects of adipose tissue function in PCOS are abnormal, and these abnormalities likely predispose to development of insulin resistance even in the absence of obesity. This review provides an overview of these abnormalities and their impact on development of metabolic disorders. At the end, an overview of the therapeutic options for management of adiposity and its complications in PCOS are discussed.

References

Aug 1, 1992·The Journal of Clinical Endocrinology and Metabolism·T P CiaraldiS S Yen
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·R PasqualiL Barbara
Nov 1, 1985·The Journal of Clinical Endocrinology and Metabolism·R A WildG B Ranney
Dec 1, 1994·Metabolism: Clinical and Experimental·P J MarsdenR Taylor
Dec 1, 1993·Journal of Internal Medicine·P Björntorp
Aug 1, 1996·The Journal of Clinical Investigation·K RebrinR N Bergman
Apr 1, 1996·European Journal of Clinical Investigation·S B PedersenB Richelsen
Jun 27, 1998·Lancet·P Arner
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·R S LegroA Dunaif
Oct 24, 2000·Trends in Endocrinology and Metabolism : TEM·R N Bergman, M Ader
Jun 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·I LemieuxJ P Després
Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A FestaS M Haffner
Jan 5, 2002·The American Journal of Medicine·R S LegroA Dunaif
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Gary FauldsPeter Arner
Oct 1, 2003·Trends in Endocrinology and Metabolism : TEM·Susan Sam, Andrea Dunaif
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Dec 18, 2003·The Journal of Clinical Investigation·Haiyan XuHong Chen
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Erin E Kershaw, Jeffrey S Flier
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Ricardo AzzizBulent O Yildiz
Nov 13, 2004·The Journal of Clinical Endocrinology and Metabolism·V JayagopalS L Atkin
Dec 30, 2004·The Journal of Clinical Endocrinology and Metabolism·Teimuraz ApridonidzeJohn E Nestler
May 19, 2005·The Journal of Clinical Endocrinology and Metabolism·Susan SamAndrea Dunaif
Sep 29, 2005·The Journal of Clinical Endocrinology and Metabolism·Héctor F Escobar-MorrealeJosé L San Millán
Oct 13, 2005·The Journal of Clinical Endocrinology and Metabolism·Esra TasaliDavid A Ehrmann
Oct 27, 2005·The Journal of Clinical Endocrinology and Metabolism·David A EhrmannUNKNOWN PCOS/Troglitazone Study Group
Nov 29, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·Peter Kovacs, Michael Stumvoll
Jan 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Joan C LoAlan S Go
Apr 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Susan SamAndrea Dunaif
Aug 31, 2006·The Journal of Clinical Endocrinology and Metabolism·Ricardo AzzizUNKNOWN Androgen Excess Society
Oct 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Kaspar BerneisEnrico Carmina

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Citations

Sep 4, 2015·Molecular Nutrition & Food Research·Vasso ApostolopoulosBarbora de Courten
May 4, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Begum YildizhanTanju Pekin
Sep 1, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Weiguo LiAndrew C Larson
Dec 12, 2017·Journal of Cellular Physiology·Genmei JiaPengfei Xu
Oct 8, 2020·Revista da Associação Médica Brasileira·Maria Perez LanaMariana Jarlip

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