Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations

Journal of Exposure Science & Environmental Epidemiology
Anneclaire J De RoosAnne McTiernan

Abstract

We investigated cross-sectional associations of body composition and weight change with polychlorinated biphenyls (PCB) and organochlorine pesticides/pesticide metabolites measured in blood collected at the baseline of the Physical Activity for Total Health study of postmenopausal, overweight women living in the Seattle, Washington metropolitan area. Indicators of greater adiposity were associated with lower plasma concentrations of most PCBs with six or more chlorine atoms. This pattern was observed for current weight, body mass index, fat mass percent, subcutaneous abdominal fat, intra-abdominal fat, waist circumference, hip circumference, waist-to-hip ratio, and maximum adult weight. Conversely, PCB 105, PCB 118, and p,p'-DDE were generally increased or showed no association with these variables. Weight gain since age 35 was associated with lower concentrations of almost every organochlorine we studied, and past weight loss episodes of at least 20 pounds (≥9.1 kg) were associated with higher concentrations. Our results have implications for epidemiologic studies of organochlorines in terms of covariates that may be important to consider in statistical analyses, particularly as such considerations may differ importantly by sp...Continue Reading

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Citations

Jun 28, 2015·Environmental Monitoring and Assessment·Mario CabaCarmen Martínez-Valenzuela
Apr 12, 2014·Environmental Research·June T SpectorAnne McTiernan
Mar 23, 2013·Environment International·Govindan MalarvannanAdrian Covaci
Oct 16, 2015·The Journal of Clinical Endocrinology and Metabolism·E DirinckL F Van Gaal
Jan 12, 2017·International Journal of Environmental Research and Public Health·Feng HePaul J Arciero
Feb 4, 2014·Endocrine Reviews·Duk-Hee LeeLaura N Vandenberg
Jan 5, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Aina JansenMarit Aralt Skaug

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