Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study.

Breast Cancer Research : BCR
Rebecca RitteR Kaaks

Abstract

Associations of hormone-receptor positive breast cancer with excess adiposity are reasonably well characterized; however, uncertainty remains regarding the association of body mass index (BMI) with hormone-receptor negative malignancies, and possible interactions by hormone replacement therapy (HRT) use. Within the European EPIC cohort, Cox proportional hazards models were used to describe the relationship of BMI, waist and hip circumferences with risk of estrogen-receptor (ER) negative and progesterone-receptor (PR) negative (n = 1,021) and ER+PR+ (n = 3,586) breast tumors within five-year age bands. Among postmenopausal women, the joint effects of BMI and HRT use were analyzed. For risk of ER-PR- tumors, there was no association of BMI across the age bands. However, when analyses were restricted to postmenopausal HRT never users, a positive risk association with BMI (third versus first tertile HR = 1.47 (1.01 to 2.15)) was observed. BMI was inversely associated with ER+PR+ tumors among women aged ≤49 years (per 5 kg/m2 increase, HR = 0.79 (95%CI 0.68 to 0.91)), and positively associated with risk among women ≥65 years (HR = 1.25 (1.16 to 1.34)). Adjusting for BMI, waist and hip circumferences showed no further associations wi...Continue Reading

References

Aug 1, 1995·British Journal of Cancer·D G AltmanK A Stepniewska
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M HarveyD C Allred
Oct 26, 1999·Cancer Causes & Control : CCC·Y Yasui, J D Potter
Aug 30, 2000·Nature·C M PerouD Botstein
Apr 20, 2001·Journal of the National Cancer Institute·J McCann
Apr 20, 2001·The Proceedings of the Nutrition Society·T J KeyE Banks
Mar 20, 2002·Cancer Causes & Control : CCC·Robert E Tarone, Kenneth C Chu
Apr 18, 2002·Journal of the National Cancer Institute·T KeyUNKNOWN Endogenous Hormones and Breast Cancer Collaborative Group
Aug 21, 2002·Public Health Nutrition·Elizabeth A SpencerTimothy J Key
Nov 1, 2002·Breast Cancer Research and Treatment·William F AndersonOtis W Brawley
Nov 8, 2002·Cancer Causes & Control : CCC·Libby M MorimotoAnne McTiernan
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V Craig Jordan
Feb 5, 2004·Journal of the National Cancer Institute·Graham A ColditzSusan E Hankinson
Feb 20, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Heather Spencer FeigelsonEugenia E Calle
Jul 15, 2004·International Journal of Cancer. Journal International Du Cancer·Petra H LahmannElio Riboli
Nov 13, 2004·Breast Cancer Research : BCR·D Craig AllredDaniel Medina
Apr 25, 2006·Cancer Causes & Control : CCC·Christopher I LiJanet R Daling
Aug 19, 2006·Breast Disease·Susan E Hankinson
Oct 5, 2006·Journal of the National Cancer Institute·A Heather EliassenSusan E Hankinson
Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lena U RosenbergCecilia Magnusson
Jan 24, 2007·Breast Cancer Research : BCR·Lisa K DunnwaldChristopher I Li
Sep 19, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emad A RakhaIan O Ellis
Mar 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Agnès FournierFrançoise Clavel-Chapelon
Jun 12, 2008·Journal of the National Cancer Institute·Karyn Hede
Nov 7, 2008·International Journal of Cancer. Journal International Du Cancer·Reiko SuzukiAlicja Wolk
Mar 26, 2009·American Journal of Epidemiology·Veronica Wendy SetiawanBrian E Henderson
Jun 19, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Nov 28, 2009·Nature Reviews. Clinical Oncology·Britta Weigelt, Jorge S Reis-Filho
Feb 26, 2010·Maturitas·David P Rose, Linda Vona-Davis
Mar 17, 2010·International Journal of Cancer. Journal International Du Cancer·Kjersti BakkenFranco Berrino
Apr 13, 2010·Nature·Marie-Liesse Asselin-LabatJane E Visvader
Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Elizabeth H HammondAntonio C Wolff
Aug 12, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tanmai SaxenaGiske Ursin
Oct 21, 2010·JAMA : the Journal of the American Medical Association·Rowan T ChlebowskiUNKNOWN WHI Investigators

❮ Previous
Next ❯

Citations

Nov 28, 2012·Cancer Causes & Control : CCC·Mona JeffreysLis Ellison-Loschmann
Apr 2, 2013·Journal of the National Cancer Institute·Rowan T ChlebowskiRoss L Prentice
May 3, 2013·Journal of Bone and Mineral Metabolism·Elaine CheungAnnie W C Kung
Feb 28, 2014·Breast Cancer Research and Treatment·Thomas P AhernSusan E Hankinson
Jan 31, 2014·Breast Cancer Research and Treatment·Kristin N AndersonMaria Elena Martinez
Oct 1, 2014·Nature Reviews. Endocrinology·Rudolf Kaaks, Tilman Kühn
May 16, 2013·Climacteric : the Journal of the International Menopause Society·T J de VilliersUNKNOWN International Menopause Society
Nov 12, 2013·La Presse médicale·Anne Gompel
Dec 4, 2014·Breast Cancer Research : BCR·Anthony HowellMichelle N Harvie
Jul 25, 2015·Cancer Epidemiology·Annie S AndersonIsabelle Romieu
Nov 29, 2015·Journal of the National Cancer Institute·Lynn RosenbergJulie R Palmer
Jul 22, 2015·Cancer·Alexandra J WhiteDale P Sandler
Apr 23, 2014·International Journal of Cancer. Journal International Du Cancer·Julie HornBjørn Olav Asvold
Sep 4, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yoshimasa MiyagawaYasuo Miyoshi
Apr 15, 2015·Endocrine-related Cancer·Tim Byers, Rebecca L Sedjo
May 9, 2015·Breast Cancer Research and Treatment·Brionna Y HairMelissa A Troester
Jun 25, 2016·International Journal of Molecular Sciences·Shawna B Matthews, Henry J Thompson
Jul 20, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G-C ChenL-Q Qin
Jul 29, 2016·British Journal of Cancer·Michael E JonesAnthony J Swerdlow
Nov 8, 2015·Journal of the National Cancer Institute·Rowan T ChlebowskiRoss Prentice
Jun 2, 2017·Journal of Women's Health·Nathan L DeBonoMelissa A Troester
Apr 30, 2015·Therapeutic Advances in Drug Safety·Rowan T Chlebowski, Garnet L Anderson
Aug 13, 2014·World Journal of Clinical Oncology·Rupen ShahS David Nathanson
Mar 24, 2018·International Journal of Cancer. Journal International Du Cancer·Wenji GuoGillian K Reeves
Apr 5, 2019·International Journal of Epidemiology·Josef FritzHanno Ulmer
Aug 8, 2018·European Journal of Epidemiology·Marie Søfteland SandveiSigne Opdahl
Sep 12, 2019·International Journal of Cancer. Journal International Du Cancer·Iris CervenkaMarina Kvaskoff
Apr 8, 2020·Cancer Causes & Control : CCC·Anika HüsingRuth M Pfeiffer
Jan 4, 2017·Journal of the National Cancer Institute·Karla KerlikowskeUNKNOWN Breast Cancer Surveillance Consortium

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Methods Mentioned

BETA
hormone replacement therapy
bilateral oophorectomy
hysterectomy

Software Mentioned

SAS

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