Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans.

Obesity
Nicole EhrhardtMiklós Péterfy

Abstract

Aging is associated with impaired insulin sensitivity and increased prevalence of type 2 diabetes. However, it remains unclear whether aging-associated insulin resistance is due to increased adiposity or other age-related factors. To address this question, the impact of aging on insulin sensitivity was investigated independently of changes in body composition. Cohorts of mice aged 4 to 8 months ("young") and 18 to 27 months ("aged") exhibiting similar body composition were characterized for glucose metabolism on chow and high-fat diets. Insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamp analyses. The relationship between aging and insulin resistance in humans was investigated in 1,250 nondiabetic Mexican Americans who underwent hyperinsulinemic-euglycemic clamps. In mice with similar body composition, age had no detrimental effect on plasma glucose and insulin levels. While aging did not diminish glucose tolerance, hyperinsulinemic-euglycemic clamps demonstrated impaired insulin sensitivity and reduced insulin clearance in aged mice on chow and high-fat diets. Consistent with results in the mouse, age remained an independent determinant of insulin resistance after adjustment for body composition in Mexican Am...Continue Reading

References

Feb 1, 1991·European Journal of Clinical Investigation·D L BroughtonR Taylor
Sep 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E H LeiterL G Lipson
Oct 1, 1982·Diabetes·K L MinakerJ A Pallotta
Mar 1, 1982·Metabolism: Clinical and Experimental·C J Bailey, P R Flatt
Dec 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Annette M Chang, Jeffrey B Halter
May 17, 2003·Science·Kitt Falk PetersenGerald I Shulman
Jul 17, 2003·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Mark O GoodarziJerome I Rotter
Oct 27, 2004·Diabetes·Kristina M UtzschneiderSteven E Kahn
Aug 18, 2010·Disease Models & Mechanisms·Julio E AyalaUNKNOWN NIH Mouse Metabolic Phenotyping Center Consortium
Mar 5, 2011·Obesity·Richard N BergmanRichard M Watanabe
Feb 23, 2012·Scientific Reports·Riekelt H HoutkooperJohan Auwerx
May 24, 2012·Diabetes·Nir BarzilaiAndrzej Bartke
Sep 17, 2013·Current Diabetes Reports·Elias K Spanakis, Sherita Hill Golden
May 3, 2014·Internal Medicine·Junko OyaYasuko Uchigata
Dec 18, 2014·American Journal of Physiology. Endocrinology and Metabolism·Tiffany D FarmerMasakazu Shiota
Jan 20, 2015·Experimental Gerontology·Mélissa Lessard-BeaudoinRona K Graham
Dec 29, 2015·The Journal of Clinical Endocrinology and Metabolism·Antigoni Z LaliaIan R Lanza

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Citations

Sep 8, 2020·Diabetologia·Cristina Aguayo-Mazzucato
Feb 25, 2021·Immunity & Ageing : I & a·Heather C DenrocheC Bruce Verchere
Jun 9, 2020·Diabetes Research and Clinical Practice·Lucas Faria de CastroAngelica Amorim Amato
Sep 12, 2020·Metabolism: Clinical and Experimental·Beatriz MerinoGermán Perdomo
Mar 10, 2021·Aging·Min ZhuYounan Chen
Jun 9, 2021·Nutrition & Diabetes·Maria E Moreno-FernandezSenad Divanovic
Jul 13, 2021·American Journal of Physiology. Endocrinology and Metabolism·Julie VionDominique Langin
Aug 8, 2021·Endocrinology·Akilavalli NarasimhanLaura J Niedernhofer
Oct 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yao LiPatrick J Pagano
Oct 6, 2021·Cardiovascular Research·Gabrielle Fredman, Katherine C MacNamara
Sep 26, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eva TuduríIvan Quesada
Dec 7, 2021·Molecular Metabolism·Naoya MuraoSusumu Seino

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