Adiposity throughout adulthood and risk of sudden cardiac death in women

JACC. Clinical Electrophysiology
Stephanie E ChiuveChristine M Albert

Abstract

Sudden cardiac death (SCD) is often the first manifestation of coronary heart disease (CHD) among women. Data regarding BMI and risk of SCD are limited and conflicting. We examined the association of BMI repeatedly measured over 32 years and BMI during early and mid-adulthood with risk of SCD in the Nurses' Health Study. We prospectively followed 72,484 women free of chronic disease from 1980-2012. We ascertained adult height, current weight, and weight at age 18 at baseline and updated weight biennially. The primary endpoint was SCD (n=445). When updated biennially, higher BMI was associated with greater SCD risk after adjusting for confounders (p, linear trend: <0.001). Compared to a BMI of 21.0-22.9, the multivariate RR (95%CI) of SCD was 1.46 (1.05, 2.04) for BMI 25.0-29.9, 1.46 (1.00, 2.13) for BMI 30.0-34.9 and 2.18 (1.44, 3.28) for BMI ≥35.0. Among women with a BMI ≥35.0, SCD remained elevated even after adjustment for interim development of CHD and other mediators (RR: 1.72; 95%CI: 1.13, 2.60). In contrast, the association between BMI and fatal CHD risk was completely attenuated after adjustment for mediators. The magnitude of the association between BMI and SCD was greater when BMI was assessed at baseline or at age 18...Continue Reading

Associated Clinical Trials

May 26, 2000·JoAnn E. Manson, MD

References

May 1, 1989·Statistics in Medicine·S Durrleman, R Simon
Jan 1, 1986·American Journal of Epidemiology·G A ColditzC H Hennekens
Mar 1, 1982·Circulation·L E Hinkle, H T Thaler
Mar 15, 1995·Circulation·G WannametheeM Walker
Feb 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A PietrobelliS B Heymsfield
Jan 1, 1998·The New England Journal of Medicine·J StevensJ L Wood
Jun 16, 1999·American Journal of Epidemiology·S GreenlandW C Willett
Aug 10, 2000·American Journal of Epidemiology·I BaikW C Willett
Apr 16, 2003·Circulation·Christine M AlbertJoAnn E Manson
Aug 24, 2006·The New England Journal of Medicine·Kenneth F AdamsMichael F Leitzmann
Dec 17, 2011·American Heart Journal·Daniel A SteinhausZian H Tseng
Mar 7, 2012·Circulation·Caroline M Apovian, Noyan Gokce
May 19, 2012·Maturitas·Su-Hsin ChangGraham A Colditz
Nov 28, 2012·Journal of the American College of Cardiology·Monica L BertoiaCharles B Eaton
Mar 23, 2013·Journal of Molecular and Cellular Cardiology·Haiyan HuangJohn P Morrow
Apr 4, 2013·BMC Medicine·Dexter CanoyUNKNOWN Million Women Study Collaborators
May 21, 2013·International Journal of Cardiology·Amit NoheriaSumeet S Chugh
Aug 21, 2013·Journal of the American College of Cardiology·Anita T CoteAngela M Devlin
Nov 1, 2013·American Journal of Epidemiology·Kenneth F AdamsVictor Kipnis
Jan 22, 2014·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
May 3, 2014·American Journal of Epidemiology·Jennifer Beam Dowd, Anna Zajacova

❮ Previous
Next ❯

Citations

Apr 17, 2016·International Journal of Cardiology·Salvatore Chirumbolo
Dec 15, 2017·Journal of the American Heart Association·Gherardo FinocchiaroIacopo Olivotto
Feb 20, 2019·Circulation·M Anette E HaukilahtiM Juhani Junttila
May 21, 2019·International Heart Journal·Hui ChenShunhui Li
Jun 4, 2020·Obesity Surgery·Paulina IbacacheMarcelo Cano-Cappellacci
Apr 23, 2021·Circulation·Tiffany M Powell-WileyUNKNOWN American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; Co

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.