Adiposopathy and epigenetics: an introduction to obesity as a transgenerational disease

Current Medical Research and Opinion
Harold E Bays, Wendy Scinta

Abstract

To examine the contribution of generational epigenetic dysregulation to the inception of obesity and its adiposopathic consequences. Sources for this review included searches of PubMed, Google Scholar, and international government/major association websites using terms including adiposity, adiposopathy, epigenetics, genetics, and obesity. Excessive energy storage in adipose tissue often results in fat cell and fat organ dysfunction, which may cause metabolic and fat mass disorders. The adverse clinical manifestations of obesity are not solely due to the amount of body fat (adiposity), but are also dependent on anatomical and functional perturbations (adiposopathy or 'sick fat'). This review describes extragenetic factors and genetic conditions that promote obesity. It also serves as an introduction to epigenetic dysregulation (i.e., abnormalities in gene expression that occur without alteration in the genetic code itself), which may contribute to obesity and adiposopathic metabolic health outcomes in offspring. Within the epigenetic paradigm, obesity is a transgenerational disease, with weight lost or gained by either parent potentially impacting generational risk for obesity and its complications. Epigenetics may be an importa...Continue Reading

References

Jul 21, 2000·The Journal of Clinical Investigation·I S FarooqiS O'Rahilly
Feb 24, 2001·La Revue de médecine interne·D P Germain
Jan 25, 2003·American Journal of Human Genetics·Karin BuitingBernhard Horsthemke
Dec 13, 2005·Obesity Research·Riccardo Dalle GraveUNKNOWN QUOVADIS Study Group
Aug 17, 2006·European Journal of Human Genetics : EJHG·Jozef GéczMichael Partington
Mar 8, 2007·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Jennifer S SavageLeann L Birch
Jan 30, 2008·Basic & Clinical Pharmacology & Toxicology·I Caroline McMillenJanna L Morrison
Jan 31, 2008·Frontiers of Hormone Research·Anthony P Goldstone, Philip L Beales
Aug 7, 2008·International Journal of Clinical Practice·H E BaysUNKNOWN Adiposopathy Working Group
Mar 13, 2009·Organogenesis·Beverly Sara MühlhäuslerI Caroline McMillen
Jun 19, 2009·Advances in Experimental Medicine and Biology·I Caroline McMillenBeverley S Muhlhausler
Apr 7, 2010·Hormones : International Journal of Endocrinology and Metabolism·Andrea C Gore
Jul 14, 2010·Hormones and Behavior·James P CurleyFrances A Champagne
Jul 16, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margaret J R HeerwagenJacob E Friedman
Nov 30, 2010·The Proceedings of the Nutrition Society·Rebecca Simmons
Dec 17, 2010·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 1, 2008·Journal of Clinical Research in Pediatric Endocrinology·Fima Lifshitz
Apr 7, 2011·Maturitas·Blanca M HerreraCecilia M Lindgren
May 21, 2011·Orphanet Journal of Rare Diseases·Jean DonadieuChristine Bellanné Chantelot
Jun 3, 2011·The Journal of Clinical Investigation·Shwetha Ramachandrappa, I Sadaf Farooqi
Sep 14, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C LavebrattT J Ekström
Dec 29, 2011·Frontiers in Bioscience (Elite Edition)·Darren Green, Philip A Kalra
Jan 19, 2012·JAMA : the Journal of the American Medical Association·Katherine M FlegalCynthia L Ogden
Mar 1, 2012·International Journal of Andrology·A Janesick, B Blumberg
Jun 6, 2012·Pediatrics·Melania Manco, Bruno Dallapiccola
Jun 21, 2012·European Journal of Human Genetics : EJHG·Elizabeth Forsythe, Philip L Beales
Nov 21, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Neil A Youngson, Margaret J Morris
Mar 22, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Daniela Galliano, José Bellver
May 24, 2013·Adipocyte·Andrée-Anne HoudeLuigi Bouchard
May 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Frédéric GuénardMarie-Claude Vohl
Jun 5, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lisa M NicholasIsabella C McMillen
Jun 12, 2013·Canadian Journal of Physiology and Pharmacology·Beverly S MuhlhauslerMini A Vithayathil
Jun 12, 2013·Clinical Obstetrics and Gynecology·Michael G Ross, Mina Desai
Aug 21, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Kayla Chase, Rajiv P Sharma
Oct 2, 2013·Human Reproduction Update·Catherine E Aiken, Susan E Ozanne
Oct 31, 2013·Trends in Endocrinology and Metabolism : TEM·Amine ToubalNicolas Venteclef
Dec 4, 2013·Annals of Internal Medicine·Caroline K KramerRavi Retnakaran
Feb 26, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S J van DijkUNKNOWN Members of EpiSCOPE
Feb 27, 2014·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Mar 25, 2014·Current Atherosclerosis Reports·Harold Bays

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Citations

Feb 20, 2016·Journal of Clinical Lipidology·Harold E BaysTerry A Jacobson
Jun 4, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L WuH F Gu
Aug 17, 2016·Epigenomics·Joanna D Holbrook
Nov 8, 2016·Current Medical Research and Opinion·Harold BaysLuc Van Gaal
Mar 3, 2017·Scientific Reports·Tianshu YinWeidong Tian
Jul 14, 2018·Journal of Women's Health·Kathryn E FayNeil J Stone
Mar 2, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Eline S van der ValkElisabeth F C van Rossum
Dec 19, 2019·Frontiers in Endocrinology·Ziqiang ZhuXiaozhong Li
Dec 15, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Sarah A PriceJoseph Proietto
May 2, 2019·Frontiers in Endocrinology·Andrea G Izquierdo, Ana B Crujeiras
Apr 27, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Meetal MehtaCaroline M Apovian
Jun 3, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M P R MachadoM F Américo

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