Adipsin Concentrations Are Associated with Back Pain Independently of Adiposity in Overweight or Obese Adults

Frontiers in Physiology
Sharmayne R E BradyBarbora de Courten

Abstract

Objective: To compare cardiometabolic risk factors including cytokine and adipokine concentrations between individuals with and without back pain.Methods:In 62 overweight/obese adults (BMI ≥ 25 kg/m2; 23F/39M), we collected data on: self-reported back pain; anthropometry [BMI, waist circumference, body composition (dual energy X-ray absorptiometry-DEXA)]; metabolic parameters [fasting glucose; insulin sensitivity (hyperinsulinaemic-euglycaemic clamps)]; cardiovascular parameters (blood pressure, lipids); serum inflammation markers [high-sensitivity C-reactive protein (hsCRP; immunoturbidimetric-assay), tumor necrosis factor-alpha(TNF-α), interleukin (IL)-6, and IL-10 (multiplex-assay)]; and adipokines [leptin, adipsin, resistin, and adiponectin (multiplex-assay)].Results:Participants who reported having back pain in the past month (n= 24; 39%) had higher BMI (mean ±SD= 33.8 ± 6.3 vs. 30.2 ± 4.1 kg/m2,p= 0.008), fat-mass (39.9 ± 12.3 vs. 33.9 ± 9.8%,p= 0.04), and waist circumference (109.6 ± 16.8 vs. 101.0 ± 9.3 cm,p= 0.01) compared to those without back pain (n= 38; 61%). No differences were observed in cardiometabolic parameters, inflammatory markers, or adiponectin or resistin concentrations. Those reporting back pain had hig...Continue Reading

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Citations

Jan 17, 2019·European Journal of Nutrition·Aya MousaBarbora de Courten
Jan 19, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yunting WangWei Ren
Sep 29, 2020·Frontiers in Endocrinology·Marloes Dekker NitertBarbora de Courten
Sep 15, 2021·PloS One·Waruna L PeirisDonna M Urquhart

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