PMID: 2106533Feb 1, 1990Paper

Adjunctive clonazepam for maintenance treatment of bipolar affective disorder

Journal of Clinical Psychopharmacology
G S SachsL Jones

Abstract

In light of the reported efficacy of clonazepam in treating acute mania, we conducted a retrospective review of clinical experience with this agent in maintenance treatment of patients with bipolar affective disorder. Twenty patients with bipolar affective disorder treated with adjunctive clonazepam were identified. A case vignette and summary data on all 20 patients are presented. Clonazepam had been prescribed, in a manner similar to neuroleptics, as part of the maintenance regimen and/or on an as needed basis for acute exacerbations. In six of 17 patients previously receiving combined lithium and neuroleptic treatment, clonazepam successfully replaced the neuroleptic. Overall, eight patients were rated much improved or very much improved, including three of the five cases initially rated most severely ill. Possible mechanisms and treatment strategies are discussed.

Citations

Dec 24, 2003·Journal of Psychiatric Research·Terence A KetterYen shou Yang
Feb 14, 2003·General Hospital Psychiatry·Takahito SugimotoYuji Wada
Dec 21, 2000·Journal of Affective Disorders·C L Bowden von Knorring L
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Jul 21, 1998·Journal of Affective Disorders·M A FryeR M Post
Mar 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Dietmar WinklerSiegfried Kasper
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Oct 6, 2000·Biological Psychiatry·G S Sachs, M E Thase
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