Adjunctive Platelet-Rich Plasma (PRP) in Infrabony Regenerative Treatment: A Systematic Review and RCT's Meta-Analysis

Stem Cells International
Mubashir SaleemMaher Almasri

Abstract

The purpose of this study was to highlight the clinical performance of platelet-rich plasma (PRP) used as an adjunctive tool for regeneration in infrabony periodontal defects using different biomaterials or performing different surgical flap approaches. Comparative evaluation of main clinical outcomes as probing pocket depth reduction, clinical attachment gain, and recession reduction with and without the use of PRP has been analysed. According to the focused question, an electronic and hand searching has been performed up to December 2016. From a batch of 73 articles, the selection strategy and Jadad quality assessment led us to include 15 studies for the meta-analysis. Despite the high heterogeneity found and the lack of complete data regarding the selected clinical outcomes, a comparative analysis has been possible by the categorization of used biomaterials and surgical flap approaches. This method led us to observe the best performance of grafts with the use of adjunctive PRP in CAL gain and PPD reduction. No difference has been outlined with a specific surgical flap. Although PRP is considered a cheap and patient's derived growth factor, the not conclusive data reported would suggest that its use in addition to bone substi...Continue Reading

References

Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Nov 18, 2003·Rheumatology International·Shlomi CodishShaul Sukenik
May 12, 2006·Periodontology 2000·Giuseppe PolimeniUlf M E Wikesjö
Oct 20, 2006·Plastic and Reconstructive Surgery·Barry L EppleyMatthew Blanton
Mar 5, 2008·Journal of Periodontology·Giovanni Zucchelli, Massimo De Sanctis
Jun 23, 2009·Journal of Clinical Periodontology·Avani Rangaraju PradeepSharath Kumara Shetty
Apr 14, 2010·Implant Dentistry·Navneet S AroraGeorgios E Romanos
Nov 30, 2011·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Bharadwaj T KaushickSheeja Varghese
Jan 31, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Burcu Ozdemir, Emel Okte

❮ Previous
Next ❯

Citations

Aug 14, 2019·International Journal of Clinical Practice·Daniela Vianna PachitoRachel Riera
Jan 14, 2020·Aesthetic Surgery Journal·Naveen Virin Goddard, Norman Waterhouse
Mar 8, 2020·Australian Dental Journal·J XuS Qiu

❮ Previous
Next ❯

Methods Mentioned

BETA
chips

Software Mentioned

VCAL

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.