Adjunctive systemic hyperbaric oxygen therapy in treatment of severe prevalently ischemic diabetic foot ulcer. A randomized study

Diabetes Care
E FagliaA Morabito

Abstract

To evaluate the effectiveness of systemic hyperbaric oxygen therapy (s HBOT) in addition to a comprehensive protocol in decreasing major amputation rate in diabetic patients hospitalized for severe foot ulcer. From August 1993 to August 1995, 70 diabetic subjects were consecutively admitted into our diabetologic unit for foot ulcers. All the subjects underwent our diagnostic-therapeutic protocol and were randomized to undergo s-HBOT. Two subjects, one in the arm of the treated group and one in the arm of nontreated group, did not complete the protocol and were therefore excluded from the analysis of the results. Finally, 35 subjects received s-HBOT and another 33 did not. Of the treated group (mean session = 38.8 +/- 8), three subjects (8.6%) underwent major amputation: two below the knee and one above the knee. In the nontreated group, 11 subjects (33.3%) underwent major amputation: 7 below the knee and 4 above the knee. The difference is statistically significant (P = 0.016). The relative risk for the treated group was 0.26 (95% CI 0.08-0.84). The transcutaneous oxygen tension measured on the dorsum of the foot significantly increased in subjects treated with hyperbaric oxygen therapy: 14.0 +/- 11.8 mmHg in treated group, 5.0...Continue Reading

Citations

Jan 7, 2005·The British Journal of Surgery·I Roeckl-WiedmannP Kranke
Jul 26, 2008·International Orthopaedics·Ahmet KayaCengiz Karakuzu
Oct 28, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N EzraG Heuser
Mar 6, 2010·Bulletin of Mathematical Biology·Jennifer A FleggD L Sean McElwain
May 3, 2011·Current Diabetes Reports·Magnus LöndahlPer Katzman
Mar 1, 2012·Endocrine·Jan Apelqvist
Aug 3, 2012·Cell Stress & Chaperones·Ashley M FullerCassandra A Tierney
Apr 25, 2012·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Kleopatra Alexiadou, John Doupis
Dec 20, 2003·American Journal of Surgery·Robert G Frykberg
Jul 24, 2001·The Orthopedic Clinics of North America·C Attinger, P Cooper
Mar 15, 2003·Clinics in Plastic Surgery·William A ZamboniJohn Martinez
Sep 14, 2002·Endocrinology and Metabolism Clinics of North America·Dereck Hunt
Sep 26, 2001·Infectious Disease Clinics of North America·H G Deery, J A Sangeorzan
Jun 1, 2002·Journal of Diabetes and Its Complications·Majid KalaniKerstin Brismar
Apr 21, 2004·International Journal of Technology Assessment in Health Care·Shien GuoHomer Schmitz
Apr 11, 2008·International Journal of Technology Assessment in Health Care·Anderson W ChuckDouglas C Perry
Jul 19, 2013·International Journal of Technology Assessment in Health Care·Daria O'ReillyRon Goeree
Dec 10, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·J MasonA Booth
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jan S UlbrechtGregory M Caputo
Jun 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert C Barnes
Jun 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A R Berendt
Jun 1, 2007·Antioxidants & Redox Signaling·Harriet W Hopf, Mark D Rollins
May 23, 2007·Tissue Engineering·Jos MaldaZee Upton
Jan 31, 2006·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Mikel Gray, Catherine R Ratliff
Jun 27, 2006·Plastic and Reconstructive Surgery·H I FriedmanD Clarke
Jan 14, 2011·Plastic and Reconstructive Surgery·Stephen R Thom
Feb 21, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Paul Cianci
Jan 12, 2013·Investigative Ophthalmology & Visual Science·Hua LiuSteven E Brooks
Aug 3, 2005·American Journal of Clinical Dermatology·Binh T NgoMarc S Rendell
Oct 11, 2012·Diabetic Foot & Ankle·Alexandru V GeorgescuIrina M Capota
Jul 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Dariusz WaniczekEwa Nowakowska-Zajdel
Oct 25, 2001·Lancet·K Ouriel
Apr 12, 2014·The Journal of Surgical Research·Ching-Jen WangYur-Ren Kuo
May 7, 2014·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·N OliveiraI Cássio
Jan 3, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·T J Phillips
Sep 17, 2014·Advances in Skin & Wound Care·Gregory Ralph WeirR Gary Sibbald
Apr 16, 2014·Antioxidants & Redox Signaling·Katina M Fosen, Stephen R Thom
Aug 5, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Kyung-Chul MoonWoo-Kyung Kim
May 2, 2002·ANZ Journal of Surgery·Ian O'RourkeCherie Whitbread

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.