Adjustable Algorithmic Tool for Assessing the Effectiveness of Maternal Respiratory Syncytial Virus (RSV) Vaccination on Infant Mortality in Developing Countries.

Infectious Diseases in Obstetrics and Gynecology
Rachel CevigneyBernard Gonik

Abstract

Acute lower respiratory infection (ALRI) due to RSV is a common cause of global infant mortality, with most cases occurring in developing countries. Using data aggregated from priority countries as designated by the United States Agency for International Development's (USAID) Maternal Child Health and Nutrition (MCHN) program, we created an adjustable algorithmic tool for visualizing the effectiveness of candidate maternal RSV vaccination on infant mortality. Country-specific estimates for disease burden and case fatality rates were computed based on established data. Country-specific RSV-ALRI incidence rates for infants 0-5 months were scaled based on the reported incidence rates for children 0-59 months. Using in-hospital mortality rates and predetermined "inflation factor," we estimated the mortality of infants aged 0-5 months. Given implementation of a candidate maternal vaccination program, estimated reduction in infant RSV-ALRI incidence and mortality rates were calculated. User input is used to determine the coverage of the program and the efficacy of the vaccine. Using the generated algorithm, the overall reduction in infant mortality varied considerably depending on vaccine efficacy and distribution. Given a potential ...Continue Reading

References

Dec 3, 2014·Pediatrics in Review·Giovanni Piedimonte, Miriam K Perez
Sep 29, 2015·The Lancet. Respiratory Medicine·Natalie I MazurUNKNOWN Respiratory Syncytial Virus Network (ReSViNET)
Feb 6, 2017·Clinics in Chest Medicine·Edward E Walsh
Oct 3, 2017·Vaccine·Alexandra B HoganKathryn Glass
Nov 9, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anna C SealeJoy E Lawn
Feb 22, 2018·Pediatrics·Lakshmi SukumaranEric S Weintraub
May 17, 2018·Nature Communications·Jorge C G BlancoTrudy G Morrison
Jan 6, 2019·European Journal of Pediatrics·Ying Xing, Marijke Proesmans
May 10, 2019·Nature Communications·Morgan S A GilmanJason S McLellan

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