Adjustable maintenance dosing with budesonide/formoterol in a single inhaler provides effective asthma symptom control at a lower dose than fixed maintenance dosing

Pulmonary Pharmacology & Therapeutics
G W CanonicaCAST (Control Of Asthma By Symbicort Turbuhaler) Study Group

Abstract

Asthma guidelines suggest a stepwise approach to maintenance pharmacological treatment of persistent asthma until control is attained, and a 3 month review of the fixed maintenance dosing for step-up or step-down adjustment. This 12-week study compared the efficacy and safety of budesonide/formoterol in a single inhaler (Symbicort Turbuhaler 160/4.5 or 80/4.5 microg) given as adjustable maintenance or fixed maintenance dosing. Patients (n = 2358) were randomised to budesonide/formoterol fixed maintenance dosing (two inhalations bid) or adjustable maintenance dosing (two inhalation bid; stepping up to four inhalations bid if asthma worsened for a maximum of 14 days; stepping down to two inhalations once nocte or one inhalation bid if symptoms were controlled) for 12 weeks, following a 4-week run-in period on budesonide/formoterol two inhalations bid. Primary efficacy variables were frequency of asthma exacerbations and changes in patients' asthma symptom severity. Secondary variables were asthma control, safety and health economics. Both adjustable maintenance dosing and fixed maintenance dosing were associated with similar low frequency of exacerbations (5% both groups; ns) and similarly improved lung function, with similarly f...Continue Reading

Citations

May 18, 2007·The New England Journal of Medicine·UNKNOWN American Lung Association Asthma Clinical Research CentersRobert A Wise
Oct 12, 2004·American Journal of Respiratory and Critical Care Medicine·Neil C Barnes
Oct 1, 2008·Expert Review of Respiratory Medicine·Christina Lee, Jonathan Corren
Oct 7, 2010·Expert Review of Respiratory Medicine·David HodgsonTim Harrison
May 16, 2007·Expert Opinion on Investigational Drugs·Bruce K Rubin, James B Fink
Jun 29, 2007·Current Medical Research and Opinion·Steven J EdwardsDermot P Ryan
Jul 13, 2016·Immunology and Allergy Clinics of North America·Eileen Wang, Flavia C L Hoyte
Jan 1, 2008·Journal of Medical Economics·David Mg Halpin
Jul 25, 2015·The European Respiratory Journal·Helen K ReddelJ Mark FitzGerald
Jun 19, 2009·American Journal of Respiratory and Critical Care Medicine·Helen K ReddelUNKNOWN American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations
Sep 26, 2019·The Cochrane Database of Systematic Reviews·Sadia JanjuaChristopher J Cates
Jun 8, 2013·The Cochrane Database of Systematic Reviews·Christopher J CatesMontse Ferrer
Dec 21, 2004·Treatments in Respiratory Medicine·K Fan Chung, Ian M Adcock
May 5, 2021·The Cochrane Database of Systematic Reviews·Iain CrossinghamTimothy Sc Hinks

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.