Adjusting copper concentrations for caeruloplasmin levels in routine clinical practice.

Journal of Clinical Pathology
Patrick J TwomeyAnthony S Wierzbicki

Abstract

An investigation on copper metabolism usually includes the measurement of serum levels of copper and caeruloplasmin. Using these levels, some laboratories derive levels of non-caeruloplasmin-bound copper (NCC); however, a considerable number of patients may show negative values, which is not physiologically possible. To derive an equation for adjusted copper in a manner similar to that widely accepted for adjusted calcium. A linear regression equation for the relationship between caeruloplasmin and copper was used: [copper] (micromol/l) = 0.052x[caeruloplasmin] (mg/l). An equation for copper adjusted for caeruloplasmin was derived using this equation and the reference interval of 10-25 micromol/l for copper. The derived equation was [adjusted copper] (micromol/l) = [total copper] (micromol/l)+0.052x[caeruloplasmin] (mg/l)+17.5 (micromol/l). The adjusted copper concentrations on the 2.5th and 97.5th centiles were 12.7 and 21.5 micromol/l, respectively, with the population having a gaussian distribution. The relationship between NCC and the adjusted copper concentrations is linear and independent of caeruloplasmin concentration. Calculation of copper adjusted for caeruloplasmin uses the same variables as those for NCC. Accordingl...Continue Reading

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Citations

Dec 6, 2011·Journal of Neural Transmission·Yuval Eliahu LandauAlan Apter
Apr 5, 2007·Journal of Clinical Pathology·Patrick J TwomeyAnthony S Wierzbicki
Jun 24, 2008·Critical Reviews in Clinical Laboratory Sciences·Chloe M Mak, Ching-Wan Lam
Aug 31, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Neeraj KumarMary F Burritt
May 15, 2007·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Patrick J Twomey
Apr 1, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Callum Livingstone
Aug 26, 2011·European Neurology·Helen Ling, Roongroj Bhidayasiri
Feb 16, 2020·Journal of Clinical Pathology·Janice Lv ReevePatrick J Twomey
Dec 5, 2019·Journal of Clinical Pathology·Kok-Siong PoonKaren Tan
Apr 1, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Callum Livingstone
Jul 17, 2007·Biochemistry·Lorna E Wilkinson-White, Simon B Easterbrook-Smith
Jul 18, 2021·Analytical and Bioanalytical Chemistry·M Estela Del Castillo BustoHeidi Goenaga-Infante

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