Adjusting for Drug Wastage in Economic Evaluations of New Therapies for Hematologic Malignancies: A Systematic Review

Journal of Oncology Practice
Karen LienKelvin K W Chan

Abstract

As costs of cancer care rise, there has been a shift to focus on value. Drug wastage affects costs to patients and health care systems without adding value. Historically, cost-effectiveness analyses have used models that assume no drug wastage; however, this may not reflect real-world practices. We sought to identify the frequency of drug wastage modeling in economic evaluations of modern parenteral therapies for hematologic malignancies. We conducted a systematic literature review of economic evaluations of new US Food and Drug Administration-approved parenteral chemotherapies with indications for the treatment of hematologic malignancies. The primary outcome of interest was the proportion of studies that modeled drug wastage in base-case analyses. If wastage was considered in primary analyses, we reported the impact of wastage on incremental cost-effectiveness ratios (ICERs) and drug acquisition costs. Wastage was considered in base-case analyses in less than one third of all publications reviewed (12 of 38; 32%). Of these, two studies went on to complete sensitivity analyses and reported significant changes in the calculated ICER as a result. In one study, the ICER increased by 32%, and in the second, accounting for wastage ...Continue Reading

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Jun 8, 2017·Future Oncology·Peter J GilbarErin C Gilbar
Oct 5, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott F HuntingtonSapna A Prasad
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Jan 8, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kishan K PatelScott F Huntington
May 4, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·Ziyan ChenVakaramoko Diaby

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