Adjusting fracture probability by trabecular bone score

Calcified Tissue International
Eugene McCloskeyJohn A Kanis

Abstract

The aim of the present study was to determine the impact of trabecular bone score on the probability of fracture above that provided by the clinical risk factors utilized in FRAX. We performed a retrospective cohort study of 33,352 women aged 40-99 years from the province of Manitoba, Canada, with baseline measurements of lumbar spine trabecular bone score (TBS) and FRAX risk variables. The analysis was cohort-specific rather than based on the Canadian version of FRAX. The associations between trabecular bone score, the FRAX risk factors and the risk of fracture or death were examined using an extension of the Poisson regression model and used to calculate 10-year probabilities of fracture with and without TBS and to derive an algorithm to adjust fracture probability to take account of the independent contribution of TBS to fracture and mortality risk. During a mean follow-up of 4.7 years, 1754 women died and 1639 sustained one or more major osteoporotic fractures excluding hip fracture and 306 women sustained one or more hip fracture. When fully adjusted for FRAX risk variables, TBS remained a statistically significant predictor of major osteoporotic fractures excluding hip fracture (HR/SD 1.18, 95% CI 1.12-1.24), death (HR/SD...Continue Reading

References

Oct 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K G FaulknerH K Genant
Dec 16, 1998·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A C LookerR Lindsay
Sep 30, 2003·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·William D Leslie, Colleen Metge
Feb 22, 2005·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·William D LeslieGregory S Finlayson
Oct 13, 2006·The Journal of Clinical Endocrinology and Metabolism·William D LeslieUNKNOWN Manitoba Bone Density Program
Jan 20, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A Díez-PérezUNKNOWN Ecografía Osea en Atención Primaria study investigators
Feb 27, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisN Yoshimura
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisE McCloskey
Aug 30, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN National Osteoporosis Guideline Group
Sep 5, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lang YangRichard Eastell
May 26, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·William D LeslieUNKNOWN Manitoba Bone Density Program
Oct 21, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W D LeslieJ A Kanis
Jan 14, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisE V McCloskey
Sep 3, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Didier HansWilliam D Leslie
Mar 7, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·William D LeslieUNKNOWN Manitoba Bone Density Program
Apr 28, 2012·BMC Public Health·Lisa M LixWilliam D Leslie
Aug 14, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roberto C Güerri-FernándezAdolfo Díez-Pérez
Sep 29, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Albrecht W PoppKurt Lippuner
Oct 12, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M A KriegUNKNOWN Manitoba Bone Density Program
Sep 14, 2013·Archives of Osteoporosis·J A KanisJ Stenmark
Oct 12, 2013·Journal of Medical Devices·Connor RandallPaul K Hansma
Jan 21, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Barbara C SilvaJohn P Bilezikian
Feb 13, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yohann BalaEgo Seeman
Jun 22, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W D LeslieD Hans

❮ Previous
Next ❯

Citations

Aug 4, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ghislain MaquerPhilippe K Zysset
Aug 3, 2016·Current Radiology Reports·Ursula HeilmeierThomas M Link
Nov 26, 2015·Expert Opinion on Pharmacotherapy·Paul D Miller
Jan 12, 2016·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·E Michael LewieckiPaul D Miller
Mar 10, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A C LookerJ A Shepherd
Sep 18, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John T SchousboeUNKNOWN Osteoporotic Fractures in Men MrOS Study Research Group
Mar 22, 2016·Endocrinology and Metabolism·Yong Jun Choi
Nov 27, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K L NaylorW D Leslie
Aug 19, 2015·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Barbara C SilvaWilliam D Leslie
Aug 5, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Catherine CormierJean-Claude Souberbielle
Nov 5, 2016·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Yong Jun ChoiYoon-Sok Chung
Oct 27, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eugene V McCloskeyJohn A Kanis
May 11, 2016·Current Opinion in Rheumatology·Eugene V McCloskeyJohn A Kanis
Jul 29, 2016·Archives of Osteoporosis·John A KanisUNKNOWN Advisory Board of the National Osteoporosis Guideline Group
Aug 28, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y SuT Kwok
Oct 11, 2016·Aging Clinical and Experimental Research·Gloria BonaccorsiGiuseppe Guglielmi
Oct 21, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lisa LangsetmoUNKNOWN Osteoporotic Fractures in Men (MrOS) Research Group
Nov 1, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Kyla L NaylorWilliam D Leslie
Nov 1, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Sharon M Moe, Thomas L Nickolas
Dec 10, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·William D LeslieLisa M Lix
Feb 6, 2017·Bone·Sarah L Morgan, Ginnie L Prater
Sep 7, 2016·Calcified Tissue International·G Isanne Schacter, William D Leslie
Mar 10, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Patrick MartineauJohn A Kanis
Sep 1, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Patrick MartineauWilliam D Leslie
Sep 5, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N K HydeJ A Pasco
Oct 12, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N BinkleyD Hans
Nov 6, 2017·Current Osteoporosis Reports·Sharon H Chou, Meryl S LeBoff
Jun 29, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·William D LeslieDidier Hans
Nov 2, 2018·Archives of Osteoporosis·John A KanisEugene V McCloskey
Feb 3, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W D LeslieD Hans
Mar 30, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Matthew LuckmanThomas L Nickolas
Aug 17, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Enisa ShevrojaDidier Hans
Feb 12, 2020·Aging Clinical and Experimental Research·John A KanisEugene V McCloskey
Jul 28, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M R McClungC Libanati
Jun 3, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R K Jain, T Vokes
Nov 22, 2018·JBMR Plus·Matthew J Damasiewicz, Thomas L Nickolas
Oct 17, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committe
Sep 28, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E M LewieckiA J Singer
Mar 13, 2018·Current Opinion in Rheumatology·Patrick Martineau, William D Leslie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
William D LeslieD Hans
Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
William D LeslieManitoba Bone Density Program
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Laura E TargownikWilliam D Leslie
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Lora M GiangregorioJohn A Kanis
© 2021 Meta ULC. All rights reserved