Adjuvant and neoadjuvant radiotherapy for bladder cancer: revisited

Future Oncology
M S Zaghloul

Abstract

To date, radical cystectomy has continued to be the treatment of choice for muscle-invasive bladder cancer. It is associated with a 5-year disease-free survival rate ranging from 27-55%. This outcome is significantly worse when reporting upon locally advanced cases. The independent prognostic factors include: tumor stage, grade, pelvic nodal involvement and some other additional factors. Beside the higher reported incidence of distant metastasis, local recurrence either alone or combined with systemic relapse has been shown to be experienced by 23-50% of locally advanced patients - a rate that was much more frequent than previously believed. Nonrandomized trials of preoperative radiotherapy have suggested improved survival rates. However, only one out of the six randomized preoperative trials in the literature published in English has proved to be significant. On the other hand, the only randomized trial and most retrospective studies dealing with postoperative radiotherapy revealed a significant increase in disease-free survival. Late complications of post operative radiotherapy, contrary to former belief, were acceptable and generally depended upon the volume of the irradiated normal tissues and the radiotherapy techniques us...Continue Reading

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Citations

Sep 2, 2015·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Brian C BaumannJohn P Christodouleas
Nov 20, 2012·Journal of the Egyptian National Cancer Institute·Mohamed S Zaghloul
Apr 4, 2015·Hematology/oncology Clinics of North America·Jeffrey J LeowJoaquim Bellmunt
Sep 1, 2013·Journal of Advanced Research·Hussein Khaled
Mar 10, 2012·International Journal of Radiation Oncology, Biology, Physics·Kevin R KozakJohn S Moody
May 1, 2016·International Journal of Radiation Oncology, Biology, Physics·Mohamed Saad Zaghloul
Aug 14, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Alessandro LeonettiSebastiano Buti
Oct 15, 2010·Expert Review of Anticancer Therapy·Mohamed Saad Zaghloul
Nov 30, 2010·Expert Review of Anticancer Therapy·Mohamed S Zaghloul, Amr G Mousa
Jun 22, 2012·Expert Review of Anticancer Therapy·Mohamed S Zaghloul, Iman Gouda
May 11, 2011·Expert Review of Anticancer Therapy·Mohamed Saad Zaghloul
Dec 1, 2020·Journal of the Egyptian National Cancer Institute·Mohamed S ZaghloulBrian C Baumann
Jan 4, 2021·World Journal of Urology·Boda Guo, Ming Liu
Dec 16, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Boda Guo, Ming Liu

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Methods Mentioned

BETA
dissection
biopsy
irradiate
irradiating

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