Adjuvant and neoadjuvant systemic therapy for pancreas adenocarcinoma

Seminars in Oncology
Daneng Li, Eileen M O'Reilly

Abstract

The last two decades of research in the adjuvant setting of pancreas adenocarcinoma have established the value of adjuvant systemic therapy as being able to delay recurrence and increase overall survival. International standards of care in the adjuvant setting include either 6 months of gemcitabine or 5-fluorouracil and leucovorin. The added value of additional agents in the adjuvant setting is being evaluated in several large adjuvant studies. The role of a targeted agent in the adjuvant setting remains investigational. Other major areas of exploration include the integration of adjuvant immunotherapeutic approaches, which provide promise in a setting of micrometastatic disease volumes where such approaches may have greatest value.

References

Jul 1, 1992·American Journal of Surgery·I H NordbackJ L Cameron
Nov 22, 2001·Lancet·R A AbramsS Piantadosi
Nov 22, 2001·Lancet·J P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Mar 19, 2004·The New England Journal of Medicine·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Mar 19, 2004·The New England Journal of Medicine·Michael A Choti
Apr 25, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm J MooreUNKNOWN National Cancer Institute of Canada Clinical Trials Group
May 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan HeinrichPierre-Alain Clavien
Jul 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michele M CorsiniLeonard L Gunderson
Feb 27, 2009·Expert Opinion on Investigational Drugs·Muhammad Wasif SaifNikos A Katirtzoglou
Apr 21, 2009·Gastroenterology·Andrew V BiankinUNKNOWN NSW Pancreatic Cancer Network
May 30, 2009·Journal of the American College of Surgeons·Nipun B MerchantAlexander A Parikh
Feb 9, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gaetan Des GuetzBernard Uzzan
Feb 26, 2010·Nucleosides, Nucleotides & Nucleic Acids·Vijaya L DamarajuCarol E Cass
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Synne WedénTrond Buanes
Aug 6, 2010·American Journal of Clinical Oncology·Ghassan K Abou-AlfaEileen M O'Reilly
Sep 9, 2010·JAMA : the Journal of the American Medical Association·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Sep 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Luc Van LaethemKarin Haustermans
Oct 10, 2013·JAMA : the Journal of the American Medical Association·Helmut OettleHanno Riess
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

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Citations

Sep 14, 2015·Surgical Oncology Clinics of North America·Ashton A Connor, Steven Gallinger
Sep 14, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ali A MokdadPatricio M Polanco
Dec 14, 2019·PloS One·Matthew N WatersBenjamin C Webster
Feb 6, 2017·Journal of Magnetic Resonance Imaging : JMRI·Elizabeth M HechtJohn A Chabot
Sep 12, 2019·Frontiers in Oncology·Olorunseun O Ogunwobi, Adithya Kumar
Dec 31, 2019·World Journal of Gastroenterology : WJG·Keiichi Okano, Yasuyuki Suzuki
Aug 5, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nicolas A FraunhofferNelson Dusetti

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