Adjuvant antiviral therapy for hepatitis B virus-related hepatocellular carcinoma after curative treatment: A systematic review and meta-analysis

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Gao-Min LiuBao-Gang Peng

Abstract

To investigate whether adjuvant antiviral treatment could improve prognosis and entecavir is the optimal nucleoside/nucleotide analog (NA) regimen after curative therapy of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). A comprehensive electronic search was performed. All controlled trials comparing antiviral treatment with placebo or no treatment for HBV-related HCC after curative treatment were included. The pooled hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Stata 12.0 software. An indirect treatment comparison method was used to compare the relative efficacy of different NA strategies. Twenty-one studies containing 8072 patients were included. NA was found to significantly improve recurrence-free survival (RFS) and overall survival (OS). Alternatively, for interferon, a non-significant benefit was found. By adjusted indirect comparisons among entecavir, lamivudine and adefovir, entecavir were found to display almost but not significant superiority to the other NA in improving RFS. No tendency favoring a specific NA regimen was found for OS. In HBV-HCC patient after curative treatment, NA improve the prognosis significantly but the role of interferon remains to be elucidated; en...Continue Reading

References

Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J P VilleneuveE J Heathcote
Oct 8, 2004·The New England Journal of Medicine·Yun-Fan LiawUNKNOWN Cirrhosis Asian Lamivudine Multicentre Study Group
Jul 19, 2005·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Akihiro MatsumotoUNKNOWN Inuyama Hepatitis Study Group
Feb 16, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shoji KuboShuhei Nishiguchi
Sep 5, 2008·PharmacoEconomics·Alex SuttonKeith Abrams
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Nov 23, 2011·Annals of Surgery·Li-Tzong ChenUNKNOWN Disease Committee of Adjuvant Therapy for Postoperative Hepatocellular Carcinoma, Taiwan Cooperative Oncology Group, Nationa
Feb 4, 2012·Journal of Hepatology·Carlos Rodríguez de LopeJordi Bruix
Apr 28, 2012·Gastroenterology·Hashem B El-Serag
May 25, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T YangM-C Wu
Jul 19, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ching-Lung Lai, Man-Fung Yuen
Apr 24, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ping SunQi-Chang Zheng
May 25, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroki NishikawaYukio Osaki
Sep 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jianhua YinGuangwen Cao
Jun 1, 2009·Clinical Journal of Gastroenterology·Riki OkitaKiwamu Okita
Jun 1, 2012·Hepatology International·Yun-Fan LiawMasao Omata

❮ Previous
Next ❯

Citations

Dec 21, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rahul Gupta, Jyoti Gupta
Jul 1, 2017·Expert Review of Gastroenterology & Hepatology·Yiqi YuWenhong Zhang
Apr 11, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Li XieGuihua Zhuang
Sep 14, 2016·World Journal of Gastroenterology : WJG·Taro TakamiIsao Sakaida
Oct 28, 2019·Expert Review of Gastroenterology & Hepatology·Shi-Dong LuJian-Hong Zhong
Dec 5, 2019·World Journal of Gastrointestinal Oncology·Zi-Lin HuangLu-Jun Shen
Feb 7, 2020·Journal of Clinical and Experimental Hepatology·Ashish KumarUNKNOWN INASL Task-Force on Hepatocellular Carcinoma
Mar 24, 2021·Frontiers of Medicine·Wei ZhangXiao-Ping Chen
Nov 12, 2021·Journal of Gastrointestinal Cancer·Murat Harputluoglu, Brian I Carr

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.