Adjuvant Bisphosphonates and Breast Cancer Survival

Annual Review of Medicine
Stephanie StroblMichael Gnant

Abstract

Randomized trials have studied bisphosphonates in the adjuvant setting of early breast cancer to investigate their ability to prevent treatment-induced bone loss. Trial results have also suggested their potential to prevent disease recurrence and metastases. These trials are summarized in this review. A recent patient-level meta-analysis by the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) finds convincing evidence that adjuvant antiresorptive treatments provide persistent benefits to breast cancer patients in low-estrogen situations and should be considered an important part of the treatment algorithm.

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Sep 14, 2016·International Journal of Molecular Sciences·Sandra CasimiroLuis Costa
Mar 24, 2018·The Journal of International Medical Research·Hai-Jun WangYong Li
Jan 19, 2018·Therapeutic Advances in Medical Oncology·Kerstin WimmerMichael Gnant
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Jun 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Xinkui LiuXiaomeng Zhang
Sep 30, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gad RennertHedy S Rennert

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