Adjuvant Carboplatin Treatment in 115 Patients With Stage I Seminoma: Retrospective Multicenter Survey

Clinical Genitourinary Cancer
Alberto DiminuttoVittorina Zagonel

Abstract

The administration of carboplatin AUC 7 has become a standard adjuvant option for patients undergoing orchiectomy for stage I seminoma, in alternative to radiotherapy on retroperitoneal lymphnodes or surveillance. The toxicity of AUC 7 carboplatin appeared manageable in the pivotal trial of Oliver et al, but dose ranges were not reported. Fear of toxicity may induce arbitrary dose reductions, which may potentially compromise patients' outcome. We reviewed adjuvant carboplatin administration in 115 stage I seminoma patients followed in 11 Italian medical oncology centers since 2005. Clinical and pathological data, modality of carboplatin dose calculation, dose reductions, toxicities, and relapses were recorded. Median age was 35 years (range, 18-65 years), adverse prognostic factors were either T ≥ 4 cm (17.4%) or rete testis invasion (28.7%), both of them (35.7%), none or unspecified (18.3%). GFR was estimated mainly by Cockroft-Gault formula (55.7%) or Jeliffe formula (26.1%), with a median of 105 mL/min (range, 75-209 mL/min). The median dose of carboplatin was 900 mg (range, 690-1535 mg). A dose reduction > 10% was applied to 14 patients. Toxicities were mild fatigue, moderate nausea/vomiting, 5.2% of grade 3 to 4 thrombocyt...Continue Reading

References

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Citations

May 10, 2017·Future Oncology·Suliman BoulosHan Hsi Wong
Jul 26, 2018·Current Opinion in Urology·Rodrigo Suarez-IbarrolaShahrokh F Shariat
Apr 27, 2016·Journal of Cancer Research and Clinical Oncology·Klaus-Peter DieckmannUNKNOWN German Testicular Cancer Study Group
Nov 29, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefanie FischerSilke Gillessen
May 8, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K-P Dieckmann, P Anheuser

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