Adjuvant CCNU (lomustine) and prednisone chemotherapy for dogs with incompletely excised grade 2 mast cell tumors

Journal of the American Animal Hospital Association
Kenji HosoyaC Guillermo Couto

Abstract

The use of adjuvant 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; lomustine) to treat incompletely excised canine mast cell tumors (MCTs) has not been evaluated. Medical records of 12 dogs with grade 2 MCT treated with incomplete surgical excision and adjuvant CCNU and prednisone chemotherapy were reviewed. Local recurrence rate, metastasis rate, and survival time were evaluated. None of the dogs developed local recurrence or regional/ distant metastases. Two dogs developed fatal liver failure. The 1- and 2-year progression-free rates of surviving dogs were 100% and 77%, respectively. Postoperative adjuvant CCNU appears to be a useful alternative to radiation therapy for incompletely excised canine cutaneous MCTs.

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Citations

Mar 25, 2014·Journal of the American Animal Hospital Association·Kenneth M RassnickJoanne L Intile
Aug 14, 2012·Veterinary and Comparative Oncology·L BlackwoodD J Argyle
Mar 3, 2015·The Journal of Small Animal Practice·S van LelyveldJ Dobson
Sep 25, 2020·American Journal of Veterinary Research·Andrea M DedeauxBonnie B Boudreaux
Jun 20, 2018·Frontiers in Veterinary Science·Galina V IlyinskayaPeter M Chumakov
Nov 15, 2021·Veterinary and Comparative Oncology·Thomas ChavalleFrédérique Ponce

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