Abstract
To evaluate the efficacy of adjuvant chemoradiation therapy (CRT) for pancreatic adenocarcinoma patients ≥ 75 years of age. The study group of 655 patients underwent pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma at the Johns Hopkins Hospital over a 12-year period (8/30/1993 to 2/28/2005). Demographic characteristics, comorbidities, intraoperative data, pathology data, and patient outcomes were collected and analyzed by adjuvant treatment status and age ≥ 75 years. Cox proportional hazards analysis determined clinical predictors of mortality and morbidity. We identified 166 of 655 (25.3%) patients were ≥ 75 years of age and 489 of 655 patients (74.7%) were <75 years of age. Forty-nine patients in the elderly group (29.5%) received adjuvant CRT. For elderly patients, node-positive metastases (p = 0.008), poor/anaplastic differentiation (p = 0.012), and undergoing a total pancreatectomy (p = 0.010) predicted poor survival. The 2-year survival for elderly patients receiving adjuvant therapy was improved compared with surgery alone (49.0% vs. 31.6%, p = 0.013); however, 5-year survival was similar (11.7% vs. 19.8%, respectively, p = 0.310). After adjusting for major confounders, adjuvant therapy in elderly patients had ...Continue Reading
References
Oct 1, 1995·Annals of Surgery·C J YeoH A Pitt
Sep 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J M de RijkeP A van den Brandt
Oct 20, 2000·American Journal of Clinical Oncology·T WasilS Rush
Nov 22, 2001·Lancet·J P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Nov 5, 2003·Annals of Surgical Oncology·David A EtzioniClifford Y Ko
Mar 19, 2004·The New England Journal of Medicine·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharon H GiordanoMelissa L Bondy
Aug 12, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G FreyerE Pujade-Lauraine
Feb 24, 2006·Archives of Surgery·Stefania BrozzettiAntonino Cavallaro
Mar 1, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Martin A MakaryCharles J Yeo
Jun 29, 2006·Alimentary Pharmacology & Therapeutics·Y H ShaibH B El-Serag
May 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Claude Horiot
May 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Miriam B Rodin, Supriya G Mohile
Jul 13, 2007·The New England Journal of Medicine·Stephen Hanna
Nov 13, 2007·Gastroenterology Clinics of North America·Ralph H HrubanMichael Goggins
Jul 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph M HermanRoss Abrams
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jun 11, 2009·Cancer·Jona A HattangadiHarvey J Mamon
Jan 21, 2010·Annals of Surgical Oncology·Charles C HsuRobert C Miller
Citations
Sep 29, 2011·Radiation Oncology·Amol K NarangJoseph M Herman
Oct 18, 2013·Radiation Oncology·Carolyn H KimSteven A Burton
Oct 17, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ching-Wei D TzengThomas A Aloia
Mar 15, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I H KunklerUNKNOWN SIOG Radiotherapy Task Force
Feb 7, 2015·European Journal of Cancer Care·J PeteraJ Jarkovsky
Sep 19, 2012·Seminars in Radiation Oncology·Jennifer Y WoLisa A Kachnic
Mar 22, 2016·Expert Review of Anticancer Therapy·Sten MyrehaugJoseph M Herman
Apr 19, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Shoichi KinoshitaYoshiyuki Nakajima
Sep 25, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·O TurriniUNKNOWN French Surgical Association (AFC)
Jan 4, 2015·Journal of Geriatric Oncology·Jessica M FrakesRavi Shridhar
Mar 3, 2015·Seminars in Oncology·Caitlin A McIntyre, Jordan M Winter
Jun 21, 2018·International Journal of Cancer. Journal International Du Cancer·Lei HuangHermann Brenner
Jun 1, 2014·American Journal of Clinical Oncology·Raphael L YechieliMunther Ajlouni
Nov 3, 2016·Annals of Surgical Oncology·Brent T XiaDaniel E Abbott
Apr 18, 2018·Oncotarget·John F RyanJoseph M Herman
Aug 6, 2016·Current Oncology Reports·Shin Yin LeeKevan L Hartshorn
Aug 24, 2017·Cancer Medicine·Xiaofei ZhuHuojun Zhang
Jan 27, 2016·World Journal of Gastroenterology : WJG·Oliver HigueraJaime Feliu
Jun 11, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hao LiuRakesh K Jain
Jan 3, 2021·Current Oncology Reports·Ammoren DohmRonica H Nanda