Adjuvant Chemoradiotherapy is Associated with Improved Survival for Patients with Resected Gallbladder Carcinoma: A Systematic Review and Meta-analysis

Annals of Surgical Oncology
Byoung Hyuck KimJoseph M Herman

Abstract

The impact of adjuvant radiotherapy (ART) on survival from gallbladder carcinoma (GBC) remains underexplored, with conflicting results reported. A systematic review and meta-analysis was performed to clarify the impact of ART in GBC. A systematic literature search of several databases was performed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, from inception to August 2016. Studies that reported survival outcomes for patients with or without ART after curative surgery were included. All the inclusion criteria was met by 14 retrospective studies including 9364 analyzable patients, but most of the studies had a moderate risk of bias. Generally, the ART group had more patients with unfavorable characteristics than the group that had surgery alone. Nevertheless, the pooled results showed that ART significantly reduced the risk of death (hazard ratio [HR], 0.54; 95% confidence interval [CI] 0.44-0.67; p < 0.001) and recurrence (HR 0.61; 95% CI 0.38-0.98; p = 0.04) of GBC compared with surgery alone. Exploratory analyses demonstrated a survival benefit from ART for a subgroup of patients with lymph node-positive diseases (HR 0.61; p < 0.001) and R1 resections (HR 0.55; p < 0.001...Continue Reading

References

Jun 22, 2000·The New England Journal of Medicine·J ConcatoR I Horwitz
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Mar 2, 2005·International Journal of Technology Assessment in Health Care·Stefan MichielsJean-Pierre Pignon
Jun 14, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Palat BalachandranVinay K Kapoor
Apr 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Samuel J WangPeter M Ravdin
Sep 20, 2008·Journal of Surgical Oncology·A DuffyE M O'Reilly
Mar 20, 2009·International Journal of Radiation Oncology, Biology, Physics·Douglas G GoldDavid M Nagorney
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Jan 23, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Woo Seok KimSeong Ho Choi
Jun 26, 2010·Journal of Surgical Oncology·Seong Yeon ChoTae-Hyun Kim
Jan 8, 2011·Oncology·Hyung Soon ParkJae Yong Cho
Nov 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Samuel J WangCharles R Thomas
Apr 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne M HorganJennifer J Knox
Jul 11, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Evan S GlazerSteven A Curley
Oct 24, 2012·Journal of the Korean Surgical Society·Hak Youn LeeJin Sook Jeong
Nov 8, 2013·World Journal of Surgery·Savio George BarretoShailesh V Shrikhande
Feb 28, 2014·American Journal of Clinical Oncology·Mairead G McNamaraJennifer J Knox
Mar 19, 2014·Seminars in Radiation Oncology·Terence M WilliamsCharles R Thomas
May 27, 2014·American Society of Clinical Oncology Educational Book·Bettina G MüllerManuel González Domingo
Apr 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emily Chan, Jordan Berlin
May 13, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edgar Ben-JosefCharles D Blanke
Aug 22, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Richard S HoehnDaniel E Abbott
Oct 19, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Se-Il GoJung Hun Kang
Mar 26, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jeanny KwonHong-Gyun Wu
Oct 7, 2016·Journal of the National Cancer Institute·Kalyan C MantripragadaAdam J Olszewski

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Citations

Sep 25, 2019·Expert Opinion on Pharmacotherapy·Roberto FilippiMassimo Aglietta
Mar 19, 2020·Journal of Gastrointestinal Cancer·Noori Akhtar-DaneshChristian Finley
Oct 15, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Xi-Tai HuangXiao-Yu Yin
Dec 1, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jung Ho ImJinsil Seong
Aug 15, 2021·Clinics and Research in Hepatology and Gastroenterology·Shaoming SongTiankang Guo
Sep 17, 2021·Journal of Cancer Research and Therapeutics·Sunil ChoudharyAnupam Kumar Asthana

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