Adjuvant chemotherapy for invasive bladder cancer (individual patient data).

The Cochrane Database of Systematic Reviews
Advanced Bladder Cancer (ABC) Meta-analysis Collaboration

Abstract

Controversy exists as to whether adjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite a number of randomised controlled trials. To evaluate the effect of adjuvant chemotherapy in invasive bladder cancer. We conducted a systematic review and meta-analysis of updated individual patient data from all available randomised controlled trials comparing local treatment plus adjuvant chemotherapy versus the same local treatment alone. MEDLINE and Cancerlit searches were supplemented with information from registers and hand searching meeting proceedings and also by discussion with relevant trialists and organisations. They have been regularly updated until September 2004. Trials that aimed to randomise patients with biopsy proven invasive (i.e. clinical stage T2-T4a) transitional cell carcinoma of the bladder to receive local definitive treatment with or without adjuvant chemotherapy were eligible for inclusion. We collected, validated and re-analysed updated data on all randomised patients from all available randomised trials, including 491 patients from 6 RCTs. For all outcomes, we obtained overall pooled hazard ratios using the fixed effects model. To explore the potential impact of trial design, w...Continue Reading

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Citations

Dec 17, 2009·Cancer Metastasis Reviews·William D BrandtDavid M Berman
Aug 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Walter M StadlerRichard J Cote
Jul 1, 2007·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Prathap Tharyan
Feb 24, 2009·Journal of Surgical Oncology·Sharon Sharir, Neil E Fleshner
Nov 20, 2012·Journal of the Egyptian National Cancer Institute·Mohamed S Zaghloul
Dec 8, 2019·Biological Chemistry·Constance PorriniSeav-Ly Tran
Nov 29, 2008·World Journal of Urology·Ramy F YoussefRichard J Cote
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anirban P MitraRichard J Cote
Jan 13, 2017·Der Urologe. Ausg. A·D Wilborn, S Schmidt
Jan 27, 2019·World Journal of Urology·Jeffrey J LeowArnulf Stenzl
Mar 21, 2009·Genes & Development·Jonathan E Rosenberg, William C Hahn

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