Adjuvant chemotherapy for stage I ovarian clear cell carcinoma: Patterns of use and outcomes

Gynecologic Oncology
Dimitrios NasioudisNawar A Latif

Abstract

The aim of this study was to investigate the patterns of use and outcomes of adjuvant chemotherapy for patients diagnosed with FIGO stage I ovarian clear cell carcinoma (OCCC). A cohort of patients diagnosed between 2004 and 2015 with OCCC was drawn from the National Cancer Database. Those with stage I disease who had primary surgery and underwent systematic lymphadenectomy (defined as at least 10 lymph nodes removed) were selected for further analysis. Factors associated with the administration of adjuvant chemotherapy were investigated with multivariate logistic regression. Overall survival (OS) was evaluated using Kaplan-Meier curves for patients diagnosed between 2004 and 2014, while comparisons were made with the log-rank test. Multivariate Cox analysis was performed to control for possible confounders. A total of 2325 patients met the inclusion criteria. Median age was 55 years. The majority were White (86.6%). Adjuvant chemotherapy was administered to 1839 (79.1%) patients. Hospital type and location, patient age, disease sub-stage, and year of diagnosis were independently associated with the administration of chemotherapy. Patients who received adjuvant chemotherapy (n = 1629) had better OS than those who did not (n = 4...Continue Reading

Citations

Aug 28, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dimitrios NasioudisKevin Holcomb
Jan 17, 2020·International Journal of Environmental Research and Public Health·Hao-Ting ChangJen-Ruei Chen
Aug 19, 2021·Acta Clinica Belgica·Aglaja De PauwHannelore Denys

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.

Related Papers

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Allison A GockleyMarcela G Del Carmen
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Dimitrios NasioudisKevin Holcomb
© 2022 Meta ULC. All rights reserved