Adjuvant chemotherapy in elderly patients with early breast cancer. Impact of age and comprehensive geriatric assessment on tumor board proposals

Critical Reviews in Oncology/hematology
P BarthélémyJ-E Kurtz

Abstract

Elderly breast cancer (EBC) patients are often denied adjuvant chemotherapy because of age. Breast cancer is among the most frequent cancer in Western Countries and recent data suggest that adjuvant chemotherapy could be active in selected elderly patients. We investigated the impact of age and comprehensive geriatric assessment (CGA) among other variables taken into account in tumor boards to recommend adjuvant chemotherapy in EBC patients. We retrospectively reviewed breast cancer tumor board records of all consecutive EBC patients (over 70 years old) discussed from July 2006 to July 2009 in our institution. The recorded variables included age, comorbidities, tumor stage, grade, ER/PR and HER2 status, treatment characteristics and CGA conclusions. Agreement with breast cancer treatment guidelines was verified. Reasons for deviations were recorded. A total of 192 early EBC patients files (mean age 76.7 years, range 70-98) were analyzed. Elderly patients were less likely to receive adjuvant chemotherapy even when deemed appropriate by guidelines (p<.001). Out of 118 patients with ≥1 risk factors (pT2-4, N+, RH-, SBR III), 70 were proposed adjuvant chemotherapy. In multivariate analysis, age >80 years, but not CGA result, was an...Continue Reading

References

Aug 29, 2000·Critical Reviews in Oncology/hematology·L Balducci, C Beghe
Jul 12, 2002·Journal of the American Geriatrics Society·Carol P McPhersonMartin W Lee
Jan 22, 2004·Critical Reviews in Oncology/hematology·Martine ExtermannLodovico Balducci
Aug 4, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicole Hébert-CroteauGinette Martin
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharon H GiordanoMelissa L Bondy
Jun 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharon H GiordanoJames S Goodwin
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

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Citations

Aug 2, 2012·Journal of the National Cancer Institute·M T E PutsS M H Alibhai
Dec 7, 2013·BMC Surgery·Alessandro CappellaniMassimiliano Berretta
Jun 28, 2011·The Oncologist·Jean-Philippe SpanoGilles Freyer
Dec 4, 2013·Future Oncology·Natalie TurnerLaura Biganzoli
Nov 22, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M T E PutsS M H Alibhai
May 19, 2012·World Journal of Surgical Oncology·Ruth M ParksKwok-Leung Cheung
Sep 23, 2014·Expert Opinion on Drug Safety·Omar Abdel-Rahman, Hesham ElHalawani
Jan 20, 2012·Critical Reviews in Oncology/hematology·Paolo CarliDiana Crivellari
May 25, 2013·Cancer·Michael D StubblefieldSusanne Oksbjerg Dalton
Aug 5, 2015·American Journal of Surgery·Andrea M AbbottChristine Laronga
Jan 25, 2014·Geriatrics & Gerontology International·Sophie Somana-EhrmingerValérie Quipourt
Jan 1, 2012·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Petra Tesarova
Jul 13, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D PapamichaelM Aapro
Jan 22, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J StairmandC Cunningham
Feb 14, 2012·Clinics in Geriatric Medicine·Jane Jijun Liu, Martine Extermann
May 27, 2015·Cancers·Andrew McGuireMichael J Kerin
Jul 8, 2015·Cancers·Anna Rachelle Mislang, Laura Biganzoli
Aug 15, 2017·Breast Cancer Research and Treatment·M LodiC Mathelin
Jul 13, 2019·Cancer Investigation·Farah F QuyyumiDawn L Hershman
Dec 13, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Stephanie WebsterBogda Koczwara
May 3, 2013·The Journal of Nutrition, Health & Aging·M E Rougé-BugatF Nourhashémi
May 30, 2020·Breast Cancer Research and Treatment·Cecilia T OngRachel A Greenup

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