PMID: 6166760Jul 1, 1981Paper

Adjuvant chemotherapy in non-seminomatous testis cancer: "mini-VAB" regimen: long-term followup

The Journal of Urology
D VugrinR B Golbey

Abstract

Since 40 to 50 per cent (range 20 to 80 per cent) of patients with stage II non-seminomatous germ cell tumors of the testis suffer relapse after orchiectomy and retroperitoneal lymph node dissection, relatively non-toxic adjuvant chemotherapy (consisting of vinblastine, actinomycin D, bleomycin and chlorambucil) was given to 62 patients after lymphadenectomy. Of these patients 82 per cent remained free of disease with a 4-year median followup and 18 per cent had relapse. Retrospective analysis reveals that no patient (0 of 33) with stage IIA and 38 per cent (11 of 29) with stage IIB disease had relapse. Patients with histologic evidence of extranodal extension of disease (N3 category) had the highest relapse rate (62 per cent). Based on our experience we recommend that patients with resected stage IIB disease, particularly those with extranodal extension of tumor, receive aggressive adjuvant chemotherapy.

References

May 3, 1976·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·K Höffken, C G Schmidt
Dec 1, 1978·Cancer·J P DonohueJ M Perez
Jul 1, 1971·The Journal of Urology·D G Skinner, W F Leadbetter
Sep 1, 1969·Cancer·F J AnsfieldG Ramirez

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Citations

Jan 1, 1990·Scandinavian Journal of Urology and Nephrology·J P DrozP Levasseur
Aug 1, 1984·Australasian Radiology·K W Tiver, A O Langlands

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