PMID: 3383972Apr 1, 1988Paper

Adjuvant chemotherapy in premenopausal patients with primary breast cancer; relation to drug-induced amenorrhoea, age and the progesterone receptor status of the tumour

European Journal of Cancer & Clinical Oncology
L V BeexP W Kloppenborg

Abstract

Adjuvant chemotherapy with cyclophosphamide, 5-fluorouracil and methotrexate (CMF)-induced permanent ovarian suppression in 47 of 77 (61%) premenopausal patients with axillary node positive breast cancer. After a median observation time of 37 months the relapse-free and overall survival times were significantly longer for patients with permanent amenorrhoea. A strongly positive correlation between CMF-induced amenorrhoea and age of the patients, as well as between age and the tumour PgR status, was found. The induction of ovarian suppression predominantly occurs in patients with PgR positive tumours and may add an endocrine effect to the cytotoxic action of adjuvant chemotherapy in this particular group of older premenopausal women.

References

Oct 1, 1978·Journal of Steroid Biochemistry·A J KoendersT J Benraad
Jan 1, 1983·Breast Cancer Research and Treatment·S M ThorpeB B Rasmussen

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Citations

Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P PoikonenC Blomqvist
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wendy R ParulekarUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Nov 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janice M WalsheSandra M Swain
May 5, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M VanhuyseJ Bonneterre
Aug 14, 2008·Expert Review of Anticancer Therapy·Bogda Koczwara
Sep 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Quan-Bin ZhaXin-Yu Xu

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