Adjuvant chemotherapy of childhood posterior fossa ependymoma: cranio-spinal irradiation with or without adjuvant CCNU, vincristine, and prednisone: a Childrens Cancer Group study

Medical and Pediatric Oncology
A E EvansJ L Finlay

Abstract

In 1975, members of The Children's Cancer Group (CCG) initiated a trial for patients with infratentorial medulloblastomas and ependymomas. Patients, all of whom received post-operative cranio-spinal irradiation (CSI), were randomized to receive or not receive adjuvant chemotherapy (CT) with lomustine (CCNU), vincristine, and prednisone for 1 year. Thirty-six of the 42 patients with ependymoma entered on study were suitable for analysis; 22 received combined modality therapy and 14 irradiation (RT) alone. The failure-free survival (FFS) for the entire sample at 10 years is 36% and overall survival (OS) 39%, with no difference in outcomes between the two regimens. Survival was better for females (73%) than males (21%) and for those older than 10 years (51% vs. 31%). There were two toxic deaths in the group receiving CT. We conclude from this study with long-term follow-up that the CT used was not effective in improving the outcome in children with ependymoma.

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·L J VanuytselM Brada
Jan 1, 1990·Pediatric Neurosurgery·L N SuttonR Packer
Dec 1, 1990·International Journal of Radiation Oncology, Biology, Physics·J W GoldweinG J D'Angio
Mar 1, 1990·Journal of Neurosurgery·G B NazarE B Hendrick

❮ Previous
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Citations

Feb 13, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Karen D Wright, Amar Gajjar
Mar 17, 2009·Future Oncology·Maura MassiminoFelice Giangaspero
Oct 4, 2011·Neurosurgical Focus·Daniel T NagasawaIsaac Yang
Apr 1, 1997·Brain Pathology·R L Hamilton, I F Pollack
Aug 3, 2010·Journal of Neurosurgery. Pediatrics·Martin BeneschStefan Rutkowski
Dec 22, 2007·Pediatric Neurosurgery·Helen C WangAndrew W Walter
Oct 3, 2000·Journal of Neurosurgery·D Figarella-BrangerJ F Pellissier
Oct 31, 2002·Journal of Neurosurgery·Marie-Lise C van Veelen-VincentDominique Renier
Mar 12, 2013·Seminars in Radiation Oncology·Thomas E Merchant
Jul 31, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·K VaidyaJanet R Williams
Jan 25, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M HoujamiA Benider
May 8, 2007·Critical Reviews in Oncology/hematology·Michele ReniCharles Vecht
Mar 4, 2011·Pediatric Blood & Cancer·Rajkumar VenkatramaniJonathan L Finlay
Jan 26, 2005·International Journal of Radiation Oncology, Biology, Physics·David B MansurJoseph R Simpson
Mar 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Maura MassiminoUNKNOWN AIEOP Pediatric Neuro-Oncology Group
Nov 23, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Beate TimmermannMichael Bamberg
Sep 16, 2015·Current Oncology Reports·Frank Y Lin, Murali Chintagumpala
Feb 19, 2015·Current Neurology and Neuroscience Reports·Lindsey M HoffmanMaryam Fouladi
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P ChastagnerC Kalifa
Jul 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E MerchantRobert A Sanford
Oct 21, 2009·Journal of Child Neurology·Stergios Zacharoulis, Lucas Moreno
Mar 8, 2018·Journal of Neuro-oncology·Brian DeSuzanne L Wolden
Jun 24, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E Merchant
Mar 13, 2014·Pediatric Blood & Cancer·Reuben AntonyJonathan L Finlay
Nov 13, 2018·Future Oncology·Soumen KhatuaStephen C Mack
Oct 31, 2003·Current Treatment Options in Oncology·Timothy J Moynihan
Jun 12, 2002·Current Treatment Options in Oncology·K J CohenJ Glod
Sep 6, 2007·Pediatric Neurosurgery·Raj KumarA K Mahapatra
Aug 11, 2000·Paediatric Drugs·E Bouffet
Mar 17, 2005·Pediatric Blood & Cancer·Fulya Yaman AgaogluEmin Darendeliler
Apr 11, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Wesley HsuGeorge I Jallo
Dec 22, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Shannon M MacDonald, Torunn I Yock
Feb 28, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E MerchantVijay Ramaswamy
Jul 20, 2005·Expert Review of Neurotherapeutics·Mark D Krieger, Ira E Bowen
Oct 1, 2005·Journal of Neuro-oncology·Thomas E Merchant, Maryam Fouladi
Aug 5, 2003·Paediatric Drugs·Jacques GrillKalifa Chantal
Mar 27, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·P SchüllerN Willich
Apr 18, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Thomas E Merchant
May 22, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kyu-Won ShimJoong-Uhn Choi
Jun 1, 2006·Expert Review of Neurotherapeutics·Melissa J SiegelStergios Zacharoulis
Aug 7, 2007·Expert Review of Neurotherapeutics·Darren R Hargrave, Stergios Zacharoulis
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Sabine Mueller, Susan Chang

❮ Previous
Next ❯

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