PMID: 6976488Jan 1, 1981Paper

Adjuvant chemotherapy of soft-part sarcomas with ALOMAD (S4)

Journal of Surgical Oncology
P P SordilloR B Golbey

Abstract

Sixty-four adult patients with soft-tissue sarcomas received adjuvant chemotherapy with a six-drug combination regimen after surgery. Seventy percent remain free of disease with a median follow-up of 50 months. Only seven patients have died of their disease, all within the first 24 months after surgery. Most patients experienced severe nausea and vomiting secondary to the actinomycin D and dacarbazine parts of the protocol, and three patients experienced frank Adriamycin cardiomyopathy. Toxicity from this combination was otherwise mild. The 58% recurrence rate of 12 patients who discontinued therapy early because of nausea was significantly greater than the 23% rate for those who completed or relapsed on therapy (P = 0.01). Adjuvant chemotherapy should be considered after surgery for patients with soft-part sarcomas, especially those with high-grade tumors that have a considerable risk of recurrence.

References

Nov 1, 1975·Annals of Surgery·M H ShiuJ G Fortner
Nov 7, 1974·The New England Journal of Medicine·E P CortesO Glidewell
Nov 7, 1974·The New England Journal of Medicine·N JaffeY Bishop
Jan 1, 1980·Cancer·F K StormD L Morton

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Citations

Jun 1, 1990·Journal of Surgical Oncology·R J IsraelM F Brennan
Sep 1, 1999·Journal of Pediatric Gastroenterology and Nutrition·N Al-HilalyP B Sullivan
Apr 16, 2015·Cancer·Steven I HajduPing Tang
Feb 15, 1983·Cancer·P P SordilloR B Golbey
May 1, 1985·Cancer·J C OwensS I Hajdu
Jan 1, 1989·Journal of Surgical Oncology·A I Neugut, P P Sordillo
Apr 1, 1982·Journal of Surgical Oncology·R GersonS I Hajdu
Sep 1, 1983·Journal of Surgical Oncology·M H ShiuS I Hajdu
Jan 1, 1984·Journal of Surgical Oncology·Y G AdamR Reif

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