PMID: 8591078Nov 1, 1995Paper

Adjuvant chemotherapy with 5-FU, adriamycin, and mitomycin-C (FAM) versus surgery alone for patients with locally advanced gastric adenocarcinoma: A Southwest Oncology Group study

Annals of Surgical Oncology
J S MacdonaldR Gagliano

Abstract

To evaluate FAM [5-FU (5-fluorouracil), doxorubicin, mitomycin C] chemotherapy as adjuvant therapy for patients with resected TNM stage I, II, or III gastric carcinoma. One hundred ninety-three eligible patients were accrued from 1978 to 1991 in a phase III trial comparing six cycles (1 year) of postoperative FAM chemotherapy with observation only. The median follow-up on this study was 9.5 years. For all patients, no differences (log-rank analysis) in disease-free survival (p = 0.45) and overall survival (p = 0.57) between FAM therapy (93 cases) and surgery (100 cases) were observed. Quality of surgical resection affected survival irrespective of FAM use. Cases with curative resection, defined in a retrospective review of pathology and surgical reports as cases having no evidence of residual disease in the abdomen and tumor-free margins > 1 cm, had superior survival compared to cases not meeting these requirements (p < 0.001). FAM was well tolerated with 6% (five of 90) of cases demonstrating grade IV hematologic toxicity. There were two drug-related fatalities (one cardiomyopathy, one hematolytic uremic syndrome). FAM is not effective adjuvant therapy for TNM stage I, II, and III patients with resected gastric cancer. Future ...Continue Reading

References

Mar 1, 1978·Cancer·J B DupontI Cohn
Aug 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R C CoombesA Villar-Grimalt
Jan 1, 1993·CA: a Cancer Journal for Clinicians·C C BoringT Tong

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Citations

Jun 30, 2000·Journal of Clinical Gastroenterology·R De VivoB Daniele
Apr 18, 2003·The European Journal of Surgery = Acta Chirurgica·Karl-Gunnar JanungerBengt Glimelius
Apr 13, 2006·World Journal of Gastroenterology : WJG·Yasuhiro KoderaAkimasa Nakao
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi OhtsuNagahiro Saijo
Oct 20, 2007·The British Journal of Surgery·T NakajimaUNKNOWN National Surgical Adjuvant Study of Gastric Cancer Group
Jan 11, 2013·Journal of Surgical Oncology·Mariela A BlumJaffer A Ajani
Apr 16, 2014·Scandinavian Journal of Gastroenterology·Jisen CaoTong Liu
Sep 11, 2014·World Journal of Gastroenterology : WJG·Toshifusa Nakajima, Masashi Fujii
Oct 9, 2019·Molecular Diagnosis & Therapy·Marina Alessandra PereiraEvandro Sobroza de Mello
Nov 21, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Marcus Fernando Kodama Pertille RamosIvan Cecconello
Nov 18, 2000·Current Gastroenterology Reports·J R Hecht
Apr 9, 2002·Current Oncology Reports·James C Yao, Jaffer A Ajani
Aug 23, 2005·Expert Review of Anticancer Therapy·Gauri Varadhachary, Jaffer A Ajani
May 17, 2005·Journal of Surgical Oncology·Howard Silberman
Nov 1, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S HanederJ Boda-Heggemann
Jul 1, 2010·Experimental and Therapeutic Medicine·Chiara CarlomagnoSabino DE Placido
Dec 3, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Stefan HanederJudit Boda-Heggemann
Oct 11, 2013·Journal of the National Cancer Institute·Koji ObaUNKNOWN GASTRIC group
Jul 6, 2014·Journal of Medical Imaging and Radiation Oncology·Yu Yang SoonJiade Jay Lu
Dec 7, 2018·Japanese Journal of Clinical Oncology·Hiroyuki AraiTakako Eguchi Nakajima
Feb 16, 2006·The Oncologist·Michael HejnaMarkus Raderer
May 30, 2003·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·John S Macdonald
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Sep 4, 2013·The Cochrane Database of Systematic Reviews·Rafael Diaz-NietoMarc Winslet
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Wen-Tao ShiJing-Wei Zhang
Aug 31, 2016·World Journal of Gastrointestinal Pathophysiology·Carlos León-EspinozaJoaquin Ortega-Serrano
May 17, 2005·Journal of Surgical Oncology·John S Macdonald
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lionel LimTrevor Leong
Nov 8, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Guler YavasOzlem Ata
Aug 28, 2003·Current Treatment Options in Oncology·Katsuhiko HiguchiJaffer A Ajani
Nov 15, 2011·Journal of Gastric Cancer·Seulkee ParkSung Hoon Noh
Mar 30, 2006·World Journal of Gastroenterology : WJG·Lisa HazardCourtney Scaife
Mar 2, 2013·Journal of Surgical Oncology·Sameer H PatelShishir K Maithel

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