PMID: 9167740Jun 1, 1997Paper

Adjuvant chemotherapy with doxorubicin-containing regimen for 326 stage II breast cancers: 15-year results

American Journal of Clinical Oncology
J P FerrièrePhilippe Chollet

Abstract

Between 1975 and 1986, 326 patients with stage II breast cancer were treated with an adjuvant combination of doxorubicin, vincristine, cyclophosphamide, and 5-fluorouracil (AVCF) following regional therapy (232 modified radical mastectomy, 94 lumpectomies, 304 irradiations). The AVCF regimen consisted of 4-week cycles of doxorubicin (30 mg/m2 day 1, modified radical mastectomy), vincristine (1 mg/m2 day 2), 5-fluorouracil 400 (mg/m2), and cyclophosphamide (300 mg/m2) days 3-6. Two hundred twenty-four patients (pts) had six cycles and 102 pts 12 cycles; 90 pts also received 30 mg daily tamoxifen for 1 year after chemotherapy. As of March 1994, the median follow-up was 130 months (range 86-221). One hundred eighteen pts developed recurrences (7 local, 19 controlateral, 92 metastatic) and 104 died. Estimated disease-free survival (DFS) was 5 years, 76 +/- 5%; 10 years, 64 +/- 5%; 15 years, 54 +/- 9%. Overall survival (OS) was 5 years, 85 +/- 4%; 10 years, 70 +/- 5%; 15 years, 58 +/- 10%. Survival was affected by the number of involved lymph nodes (258 pts were N+), menopausal status (OS at 15 years: 53% for MP+ and 65% for MP-) and Scarff-Bloom-Richardson grading, but not by hormonal receptors, number of courses, or associated hor...Continue Reading

References

Dec 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R BuzzoniM Zambetti
May 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherS Legault-Poisson
Oct 1, 1987·Breast Cancer Research and Treatment·W L McGuire
Jan 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G TanciniU Veronesi
Nov 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Hryniuk, H Bush

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Citations

Aug 13, 1998·Journal of Surgical Oncology·A L Feldman, J P Welch
May 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P CholletJ P Ferrière

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