Adjuvant chemotherapy with sequential or concurrent anthracycline and docetaxel: Breast International Group 02-98 randomized trial

Journal of the National Cancer Institute
Prudence A FrancisBIG 02-98 Collaborative Group

Abstract

Docetaxel is more effective than doxorubicin for patients with advanced breast cancer. The Breast International Group 02-98 randomized trial tested the effect of incorporating docetaxel into anthracycline-based adjuvant chemotherapy and compared sequential vs concurrent administration of doxorubicin and docetaxel. Patients with lymph node-positive breast cancer (n = 2887) were randomly assigned to one of four treatments: 1) sequential control (four cycles of doxorubicin at 75 mg/m2, followed by three cycles of cyclophosphamide, methotrexate, and 5-fluorouracil [CMF]); 2) concurrent control (four cycles of doxorubicin at 60 mg/m2 plus cyclophosphamide at 600 mg/m2, followed by three cycles of CMF); 3) sequential docetaxel (three cycles of doxorubicin at 75 mg/m2, followed by three cycles of docetaxel at 100 mg/m2, followed by three cycles of CMF); 4) concurrent docetaxel (four cycles of doxorubicin at 50 mg/m2 plus docetaxel at 75 mg/m2, followed by three cycles of CMF). The primary comparison evaluated the efficacy of including docetaxel regardless of schedule and was planned after 1215 disease-free survival (DFS) events (ie, relapse, second primary cancer, or death from any cause). Docetaxel and control treatment groups were c...Continue Reading

References

Dec 9, 1976·Nature·L NortonA E Bogden
Feb 19, 1976·The New England Journal of Medicine·G BonadonnaU Veronesi
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E EngelsmanR Sylvester
Dec 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R BuzzoniM Zambetti
Jan 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G TanciniU Veronesi
Dec 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P M RavdinR E Bellet
Dec 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V ValeroG N Hortobagyi
Jul 23, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J L MissetP Pouillart
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S ChanUNKNOWN 303 Study Group
Apr 13, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Di LeoM J Piccart
Jul 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emilio AlbaUNKNOWN Spanish Breast Cancer Research Group
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T R Jeffry EvansJanine L Mansi
Jun 3, 2005·The New England Journal of Medicine·Miguel MartinUNKNOWN Breast Cancer International Research Group 001 Investigators
Oct 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vernon HarveySoeren Cold
Nov 3, 2006·The New England Journal of Medicine·Christopher J PooleUNKNOWN NEAT Investigators and the SCTBG
Nov 23, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henri RochéBernard Asselain
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen E JonesLina Asmar

❮ Previous
Next ❯

Citations

Sep 23, 2009·Cancer Chemotherapy and Pharmacology·Jose PradosAntonia Aránega
Jan 5, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Orit FreedmanMark Clemons
Oct 2, 2009·Breast Cancer Research and Treatment·Sumanta K PalMark Pegram
Jun 16, 2010·Breast Cancer Research and Treatment·I Craig Henderson
Nov 11, 2009·Journal of Occupational Rehabilitation·Sophie Quinton FantoniAriane Leroyer
Dec 11, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Juan BayoAndrea Fernández
Jul 22, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Jordi GinésMiguel A Casado
Oct 1, 2013·The Breast : Official Journal of the European Society of Mastology·Marco Colleoni, Elisabetta Munzone
Dec 10, 2009·Nature Reviews. Clinical Oncology·Philippe L BedardMartine J Piccart-Gebhart
Sep 3, 2010·Nature Reviews. Clinical Oncology·Carlo PalmieriDavid Miles
Apr 28, 2011·Nature Reviews. Clinical Oncology·Elizabeth ComenJoan Massagué
Jun 20, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B C PestalozziUNKNOWN BIG 02-98 Collaborative Group
Jul 1, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E MunzoneA Goldhirsch
Oct 20, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S AebiUNKNOWN ESMO Guidelines Working Group
Apr 7, 2009·Breast Cancer Research : BCR·Sara López-Tarruella, Miguel Martín
Feb 18, 2014·Current Nutrition Reports·Maria Azrad, Wendy Demark-Wahnefried
Aug 28, 2013·Pathology Oncology Research : POR·Qing-jing FengZhi-xiang Wu
Apr 6, 2011·Breast Cancer Research and Treatment·M MartinC M Perou
Feb 15, 2013·Expert Review of Anticancer Therapy·Markus Joerger, Beat Thürlimann
Jul 16, 2008·Expert Opinion on Drug Metabolism & Toxicology·Robert Matthew Strother, Christopher Sweeney
Feb 14, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Darren L StirlandYou Han Bae
Jun 5, 2012·Cancer Treatment Reviews·Birgit E P J VriensVivianne C G Tjan-Heijnen
Sep 2, 2010·Clinical Breast Cancer·Devika GajriaChau Dang
Sep 8, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Prunella BlinmanMartin R Stockler
Sep 25, 2010·Cancer Treatment Reviews·Cyrus ChargariYoulia M Kirova
Nov 18, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicolas MagnéPaul Van Houtte
May 3, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Carmel JacobsMark Clemons
May 31, 2015·Clinical Breast Cancer·Eunpi ChoVijayakrishna K Gadi
Jun 16, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Amir SonnenblickJohn Crown
Nov 3, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Fatima CardosoUNKNOWN European Society of Breast Cancer Specialists

❮ Previous
Next ❯

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