PMID: 6165458Jul 15, 1981Paper

Adjuvant chemotherapy with VAB-3 of stage II-B testicular cancer

Cancer
D VugrinR Golbey

Abstract

A recent report from the Memorial Sloan-Kettering Cancer Center has indicated that patients with resected Stage IIB (N-2B and N-3) testicular cancer are at significant risk for relapse. Of patients with resected Stage IIB disease (N-2B, 19%; N-3, 54%), 34% relapsed after having undergone relatively mild adjuvant chemotherapy consisting of vinblastine, actinomycin D, bleomycin, and chlorambucil (VAB). In this study, 29 patients with resected Stage IIB testicular cancer underwent treatment with adjuvant VAB-3 which has been used as primary treatment for Stage III disease. All patients have remained in complete remission with a median follow-up time of 24 months. Three patients received broad spectrum antibiotics when fever and leukopenia developed. No patient experienced renal failure. The results of this study demonstrate the capability of aggressive adjuvant chemotherapy to prevent recurrence in the high-risk setting of resected Stage II (N-2B and N-3) disease. Optimal adjuvant treatment remains to be defined.

References

Dec 1, 1978·Cancer·J P DonohueJ M Perez
Jul 1, 1971·The Journal of Urology·D G Skinner, W F Leadbetter
Jul 19, 1971·JAMA : the Journal of the American Medical Association·P C WalshW E Goodwin
Nov 1, 1969·Cancer·Z N BoctorG P Murphy
Aug 15, 1981·Cancer·T F ReynoldsR B Golbey

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Citations

Apr 1, 1996·Critical Reviews in Oncology/hematology·S CulineJ P Droz
Nov 16, 2001·Journal of Inorganic Biochemistry·G PérezA Nesse
Jul 24, 1997·The New England Journal of Medicine·G J Bosl, R J Motzer
Aug 1, 1984·Australasian Radiology·K W Tiver, A O Langlands
Jan 22, 2005·Critical Reviews in Oncology/hematology·Stefania GoriMaurizio Marangolo
Sep 5, 1998·The Urologic Clinics of North America·M W Frohlich, E J Small
May 9, 2007·The Urologic Clinics of North America·G Varuni Kondagunta, Robert J Motzer
Jan 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G Varuni KondaguntaRobert J Motzer
Jan 1, 1985·Acta Radiologica. Oncology·O Dahl
May 1, 1984·The Journal of Urology·N Javadpour
Mar 1, 1984·The Journal of Urology·J E PontesR P Huben
Sep 22, 1998·Current Problems in Cancer·C R Nichols

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