Adjuvant Dose-Dense Chemotherapy for Breast Cancer: Available Evidence and Recent Updates

Breast Care
Fernando Kude de Almeida, Daniela Dornelles Rosa

Abstract

Adjuvant chemotherapy has greatly improved the prognosis of early breast cancer. Dose-dense chemotherapy seeks to increase efficacy by changing the interval between cycles of treatment without the need of increasing doses and toxicity. According to the Gompertzian model, the smaller tumors are and the more rapid they grow, the more benefit could be expected from dose-dense therapy. Some clinical trials showed reduced mortality when adjuvant chemotherapy is administered in shorter intervals, while others had discordant results. Interpreting results is difficult due to a great variability in doses and schemes used in different trials. Dose-dense chemotherapy does not seem to increase adverse events and appears to be the most efficacious in higher-risk individuals and in hormone receptor-negative tumors. This review intends to summarize the available evidence and recent research about this subject.

References

Dec 9, 1976·Nature·L NortonA E Bogden
Oct 1, 1980·The American Journal of Medicine·E Frei, G P Canellos
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I Craig HendersonLarry Norton
Dec 8, 2005·Journal of the National Cancer Institute·Marco VenturiniPaolo Bruzzi
Aug 9, 2006·Nature Clinical Practice. Oncology·Richard Simon, Larry Norton
Feb 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hannah M LindenSilvana Martino
Mar 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chau DangClifford Hudis
Apr 19, 2008·The New England Journal of Medicine·Joseph A SparanoNancy E Davidson
Nov 26, 2010·Journal of the National Cancer Institute·Luisa BonillaSalomon M Stemmer
Feb 10, 2011·The Oncologist·Sandra M Swain
Aug 14, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra M SwainNorman Wolmark
Nov 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George T BuddGabriel N Hortobagyi
Dec 23, 2014·The Breast Journal·Clifford Hudis, Chau Dang
Apr 29, 2015·Breast Cancer Research and Treatment·Fausto PetrelliSandro Barni
Jun 17, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph A SparanoNancy E Davidson
Nov 9, 2016·JAMA : the Journal of the American Medical Association·Theodoros FoukakisUNKNOWN Swedish Breast Cancer Group (SweBCG), the German Breast Group (GBG), and the Austrian Breast & Colorectal Cancer Study Group

❮ Previous
Next ❯

Citations

Jul 11, 2020·Clinical Medicine Insights. Oncology·Francesca ParisiMatteo Lambertini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Carl D Atkins
Gan to kagaku ryoho. Cancer & chemotherapy
Rika KizawaToshimi Takano
© 2022 Meta ULC. All rights reserved