Adjuvant effect of respiratory irritation on pulmonary allergic sensitization: time and site dependency

Toxicology and Applied Pharmacology
Paul D SiegelA F Hubbs

Abstract

It has been suggested that airway irritation, by acting as an adjuvant, as well as producing damage, may be an important factor related to asthma. The present study examined the window of time following acute upper and lower airway irritant exposure to determine the period of increased risk of immunological sensitization. Brown Norway rats were exposed to 87 ppm NO2 or 1000 ppm NH3 for 1 hr. A 30-min ovalbumin (OVA) exposure of 18.14 microg/liter air was given at various times based upon the time course of irritant associated inflammatory response (either immediately prior to or 1 or 7 days after the irritant exposure). OVA-only, NO2-only or NH3-only controls, and saline controls were also studied. Weekly booster exposures of OVA (or saline) were given. Circulating OVA-specific IgE, IgA, and IgG levels were quantified periodically during the 6 weeks of the study. Bronchoalveolar lavage (BAL) was also performed to examine the inflammatory response to allergic and irritant challenge. Significant increases in OVA-specific IgE, IgG, and IgA antibody titers were seen in rats given the sensitizing OVA exposure within 1 day of the NO2, but not NH3 exposures. Enhancement of cellular infiltrate in BAL was noted in groups given the sensi...Continue Reading

Citations

Dec 20, 2002·Journal of Toxicology and Environmental Health. Part a·Andrea K HubbardJohn B Morris
Nov 28, 2013·Journal of Toxicology and Environmental Health. Part a·Jitka Stilund HansenSøren Thor Larsen
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·K HamadaL Kobzik
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·T Kobayashi
Aug 27, 2002·Environmental Health Perspectives·Edward L Petsonk
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mieke BevelanderMatthew E Poynter
Apr 8, 2004·Toxicology and Industrial Health·Nabil H Al-HumadiPaul D Siegel

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