Adjuvant effects of fluoride on oral immunization of chickens

Veterinary Immunology and Immunopathology
S HoshiS Ueda

Abstract

The present study was conducted to examine the antibody responses of chickens after oral immunization and the influence of sodium fluoride (NaF) on their immunological states. Bovine serum albumin (BSA) was used as an antigen, and the response was measured by enzyme-linked immunosorbent assays of serum samples, bile samples, and lachrymal fluids. Oral immunization of chickens with antigen alone hardly induced antibody responses in sera, bile samples or lachrymal fluids. Moreover, compared to control chickens, these orally immunized chickens exhibited a lower serum IgG response to subsequent parenteral immunization, suggesting that oral immunization induced immunological tolerance in chickens. A mucosal adjuvant, NaF, could abrogate oral tolerance and elicit an increase in antibody responses. Chickens, which received oral administration of antigen and NaF simultaneously, showed a significant rise in serum IgG antibody. Although there were variations among individual chickens and the titers were low, IgA antibodies were detected in bile samples and lachrymal fluids.

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Citations

Mar 13, 2003·Developmental and Comparative Immunology·Y Zhang, J M Sharma
Mar 16, 2000·Developmental and Comparative Immunology·W I MuirA J Husband
Mar 31, 1999·Comparative Immunology, Microbiology and Infectious Diseases·S HoshiS Ueda
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Dianxin ZhangXiuhui Zhong
Nov 27, 2007·Veterinary Immunology and Immunopathology·Jian-hua SunSong-hua Hu
Feb 24, 2007·International Journal of Pharmaceutics·M HamidiS Mohammadi-Samani
Apr 5, 2003·Immunopharmacology and Immunotoxicology·Wihaskoro Sosroseno

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