Adjuvant endocrine therapy for premenopausal women with early breast cancer

Breast Cancer Research : BCR
Ting Bao, N E Davidson

Abstract

Adjuvant endocrine therapy is a pivotal component of treatment for premenopausal women with early-stage hormone receptor-positive breast cancer. Currently, the standard endocrine therapy for premenopausal women is tamoxifen; a role for ovarian suppression or ablation has also been identified. Uncertainty remains about the optimal use of endocrine therapy in this setting. The role of ovarian suppression with tamoxifen or aromatase inhibitor, the optimal duration of adjuvant endocrine therapy and the utility of biomarkers and pharmacogenetic studies to select therapy are questions worthy of further investigation.

References

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Citations

Dec 26, 2012·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Feng ChiZhaoguo Xu
May 17, 2005·Lancet·Umberto VeronesiGiuseppe Viale
Jan 29, 2009·Human Reproduction Update·M HickeyM Friedlander
Apr 24, 2009·Climacteric : the Journal of the International Menopause Society·A Nath, R Sitruk-Ware
May 22, 2008·Breast Cancer Research : BCR·Theodoros MaltarisRalf Dittrich

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Methods Mentioned

BETA
bilateral oophorectomy
prophylactic oophorectomy

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